INT122428

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Context Info
Confidence 0.00
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prkci) protein complex (Prkci) cytoplasm (Prkci)
cytosol (Prkci) extracellular space (Ighm) nucleus (Prkci)
Anatomy Link Frequency
ovary 1
Ighm (Mus musculus)
Prkci (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 99.64 Very High Very High Very High
Kinase C 3 99.56 Very High Very High Very High
Opioid 3 95.32 Very High Very High Very High
analgesia 15 92.96 High High
opioid receptor 12 90.40 High High
Morphine 12 75.00 Quite High
tolerance 3 43.04 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the association of PKCI with HmuOR reduced agonist-induced inhibition of adenylyl cyclase and suppressed HmuOR desensitization partially at the G protein level and completely at the adenylyl cyclase level.
HmuOR Binding (association) of PKCI associated with agonist
1) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.67
In this study, we found in a yeast two-hybrid screen that a protein kinase C-interacting protein (PKCI) specifically interacts with the C terminus of HmuOR.
HmuOR Binding (interacts) of PKCI associated with kinase c
2) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.50
The interaction of PKCI with HmuOR was recapitulated in Chinese hamster ovary cells that express the full-length HmuOR and PKCI proteins.
HmuOR Binding (interaction) of PKCI in ovary
3) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 0.50

General Comments

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