INT122448

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 3.67
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
Claw 2
epithelial cells 2
parathyroid 2
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 42 100.00 Very High Very High Very High
aspirin 6 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
methadone 2 100.00 Very High Very High Very High
Inflammation 2 91.84 High High
opiate 3 91.04 High High
cytokine 3 90.80 High High
imagery 3 79.48 Quite High
positron emission tomography 1 74.08 Quite High
Central nervous system 2 61.36 Quite High
Disease Link Frequency Relevance Heat
Parathyroid Cancer 9 100.00 Very High Very High Very High
Cancer 58 98.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 373 98.32 Very High Very High Very High
INFLAMMATION 2 91.84 High High
Colon Cancer 7 88.60 High High
Hypercalcemia 4 87.16 High High
Toxicity 14 84.92 Quite High
Hyperbilirubinemia 21 82.12 Quite High
Vomiting 4 73.76 Quite High
Diarrhoea 3 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of both P-gp activity and P-gp expression by Devil's Claw raise the possibility of herb-drug interactions, to be further explored in depth.


Regulation (Modulation) of Gene_expression (expression) of P-gp in Claw
1) Confidence 0.62 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.10 Pain Relevance 0
Pretreatment with sesamin for 48 h caused a significant increase in MDR1 mRNA expression without a significant effect on the expression of P-glycoprotein or accumulation of rhodamine 123.
Neg (without) Regulation (effect) of Gene_expression (expression) of P-glycoprotein
2) Confidence 0.60 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.07 Pain Relevance 0.39
Comparative effects of drugs on P-glycoprotein expression and activity using rat and human trophoblast models.
Regulation (effects) of Gene_expression (expression) of P-glycoprotein associated with aspirin
3) Confidence 0.60 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 19840843 Disease Relevance 0 Pain Relevance 0.22
Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells.
Regulation (Effects) of Gene_expression (expression) of P-glycoprotein in epithelial cells associated with qutenza
4) Confidence 0.60 Published 2010 Journal Biol. Pharm. Bull. Section Title Doc Link 20118549 Disease Relevance 0.09 Pain Relevance 0.42
Effects of selected drugs (Aspirin, Methadone, a Cardiovascular Proprietary Compound, Thalidomide) on cytotoxicity and P-gp expression and activity were compared using human and rat trophoblast cultures.
Regulation (Effects) of Gene_expression (expression) of P-gp associated with aspirin and methadone
5) Confidence 0.53 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 19840843 Disease Relevance 0 Pain Relevance 0.15
Similar pretreatment with other ingredients had little effect on the expression of MDR1 mRNA or P-glycoprotein, suggesting that they do not cause transcriptional modulation of P-glycoprotein.
Neg (little) Regulation (effect) of Gene_expression (expression) of MDR1 mRNA
6) Confidence 0.51 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.07 Pain Relevance 0.43
Similar pretreatment with other ingredients had little effect on the expression of MDR1 mRNA or P-glycoprotein, suggesting that they do not cause transcriptional modulation of P-glycoprotein.
Neg (little) Regulation (effect) of Gene_expression (expression) of P-glycoprotein
7) Confidence 0.44 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.07 Pain Relevance 0.44
We investigated the effect of morphine and/or tat on the expression of TJ proteins ZO-1, JAM-2, Occludin and P-glycoprotein and the functional effects of TJ modulation in BMVEC.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of P-glycoprotein associated with morphine
8) Confidence 0.44 Published 2008 Journal J. Clin. Immunol. Section Abstract Doc Link 18574677 Disease Relevance 0.67 Pain Relevance 0.60
Pretreatment with sesamin for 48 h caused a significant increase in MDR1 mRNA expression without a significant effect on the expression of P-glycoprotein or accumulation of rhodamine 123.
Neg (without) Regulation (effect) of Gene_expression (expression) of MDR1 mRNA
9) Confidence 0.37 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.08 Pain Relevance 0.39
Alteration in P-gp or cytochrome production or function in the elderly could possibly lead to altered responses to drugs (Bressler and Bahl 2003; Kinirons and O’Mahony 2004).
Regulation (Alteration) of Gene_expression (production) of P-gp
10) Confidence 0.26 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 0.72 Pain Relevance 0.03
Although recent studies state that expression of P-glycoprotein (P-gp) in parathyroid tumors plays an important role in the false-negative results of both 99mTc-MIBI scans and FDG-PET, immunohistological study detected no P-gp expression in the parathyroid tumor in the current case.
Regulation (role) of Gene_expression (expression) of P-glycoprotein in parathyroid associated with parathyroid cancer
11) Confidence 0.26 Published 2004 Journal Intern. Med. Section Abstract Doc Link 15497517 Disease Relevance 1.36 Pain Relevance 0.21
Thus, the present study provides further evidence that repeated exposure to dietary ingredients can cause drug-food interactions by affecting the function and mRNA expression of intestinal transporters such as P-glycoprotein.
Regulation (affecting) of Gene_expression (expression) of P-glycoprotein
12) Confidence 0.26 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0 Pain Relevance 0.23
Western blotting was performed to estimate the effect of MDR1 siRNA loaded nanoparticle on P-gp expression.
Regulation (effect) of Gene_expression (expression) of P-gp
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
M Pa alone (without light illumination) can also inhibit the P-glycoprotein expression in R-HepG2 cells, the response time is much longer (24h-incubation with Pa alone) and the mechanism is due to the regulation of MDR1 expression on transcriptional level instead of the activation of JNK [28].
Regulation (regulation) of Gene_expression (expression) of MDR1
14) Confidence 0.10 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.31 Pain Relevance 0
These results have been confirmed thereafter in patients on ATV/RTV, as patients with the CC genotype show significantly higher median ATV Ctrough concentrations than those with CT/TT genotypes (939 versus 376 ng/mL, respectively).30 The C3435T polymorphism is a silent change and thus it is unlikely that it directly influences the expression of the MDR1 gene.37 Most likely, this polymorphism may be linked to one or more other unidentified changes in MDR1 or distinct metabolizing enzyme genes.
Spec (likely) Regulation (influences) of Gene_expression (expression) of MDR1
15) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.13 Pain Relevance 0

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