INT122468

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.75
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYC1) mitochondrion (CYC1) small molecule metabolic process (CYC1)
cytoplasm (CYC1)
Anatomy Link Frequency
hepatocytes 2
myocardial cells 2
apoptotic cell 2
CYC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 96.16 Very High Very High Very High
Endep 5 93.20 High High
ischemia 24 88.08 High High
fluoxetine 4 86.56 High High
antidepressant 3 84.68 Quite High
Inflammatory mediators 1 83.04 Quite High
Glutamate 1 76.80 Quite High
Inflammation 22 75.52 Quite High
depression 3 74.64 Quite High
metalloproteinase 2 69.20 Quite High
Disease Link Frequency Relevance Heat
Death 31 99.96 Very High Very High Very High
Apoptosis 80 99.92 Very High Very High Very High
Cancer 7 99.74 Very High Very High Very High
Stress 63 99.32 Very High Very High Very High
Hypothermia 138 98.12 Very High Very High Very High
INFLAMMATION 29 95.96 Very High Very High Very High
Pressure And Volume Under Development 9 93.20 High High
Cv General 4 Under Development 1 88.96 High High
Toxicity 4 87.44 High High
Cv Unclassified Under Development 152 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both compounds prevented the loss of the mitochondrial transmembrane potential, over-expression of Bax, reduction in Bcl-2 level, cytochrome c release, caspase-3 activation, formation of reactive oxygen species and depletion of GSH.
Negative_regulation (prevented) of Localization (release) of cytochrome c
1) Confidence 0.57 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19135049 Disease Relevance 0.91 Pain Relevance 0.58
Experiments are also presented showing that NA-Gly caused a respiration-dependent large ROS production, which seems in turn to be responsible for the inhibition of electron transport activity and cytochrome c release.
Negative_regulation (inhibition) of Localization (release) of cytochrome c
2) Confidence 0.57 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19501648 Disease Relevance 0.23 Pain Relevance 0.20
Moderate hypothermia has been shown to suppress Fas-mediated apoptosis in stored cultured hepatocytes, along with suppression of cytochrome-c release from mitochondria and downstream activation of caspase-7 and caspase-9 [103].
Negative_regulation (suppression) of Localization (release) of cytochrome-c in hepatocytes associated with hypothermia and apoptosis
3) Confidence 0.57 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.00 Pain Relevance 0.21
An intracellular Ca2+ chelator partially inhibited celecoxib-induced release of cytochrome c from mitochondria, reduced the magnitude of the celecoxib-induced decrease in mitochondrial membrane potential and inhibited celecoxib-induced apoptotic cell death.
Negative_regulation (inhibited) of Localization (release) of cytochrome c in apoptotic cell associated with apoptosis and death
4) Confidence 0.42 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15987693 Disease Relevance 0.97 Pain Relevance 0.58
Indeed, it is well established that survival kinases can block apoptosis by inhibiting cytochrome c release [272].
Negative_regulation (inhibiting) of Localization (release) of cytochrome c associated with apoptosis
5) Confidence 0.42 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.89 Pain Relevance 0
Vitamin E prevents H2O2 – induced apoptosis in remote non-infarcted myocardial cells with prevention of mitochondrial cytochrome C release and activation of caspase 3 [63].
Negative_regulation (prevention) of Localization (release) of cytochrome C in myocardial cells associated with apoptosis
6) Confidence 0.42 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.79 Pain Relevance 0.08
Ibuprofen-induced Walker 256 tumor cell death: cytochrome c release from functional mitochondria and enhancement by calcineurin inhibition.
Negative_regulation (inhibition) of Localization (release) of cytochrome c associated with cancer and death
7) Confidence 0.41 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15498510 Disease Relevance 1.11 Pain Relevance 0.10
They might stimulate ROS removal as described above for the ischaemic phase or they could reduce the Bax-induced cytochrome c release.
Negative_regulation (reduce) of Localization (release) of cytochrome c
8) Confidence 0.41 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.86 Pain Relevance 0

General Comments

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