INT122472

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.66
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 6
hypothalamus 2
neurons 2
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 99.88 Very High Very High Very High
Inflammation 5 98.96 Very High Very High Very High
Peripheral nervous system 1 93.88 High High
agonist 10 93.48 High High
Action potential 4 82.44 Quite High
Hippocampus 4 81.96 Quite High
GABAergic 23 80.36 Quite High
antagonist 13 78.08 Quite High
gABA 18 76.88 Quite High
Thalamus 6 74.40 Quite High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 2 99.40 Very High Very High Very High
Diabetes Mellitus 99 99.08 Very High Very High Very High
Nociception 1 98.92 Very High Very High Very High
Colitis 4 92.56 High High
Body Weight 57 92.16 High High
Sprains And Strains 5 86.60 High High
Obesity 72 77.48 Quite High
Metabolic Syndrome 6 71.52 Quite High
Anorexia 14 61.92 Quite High
Targeted Disruption 9 61.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, it has been reported that elevation of plasma corticosterone levels is not required for the induction of NPY mRNA by fasting [15].
Neg (not) Positive_regulation (required) of Positive_regulation (induction) of NPY in plasma
1) Confidence 0.51 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.42 Pain Relevance 0
Recently, we showed that activation of the NPY Y1 receptor is required for cutaneous neurogenic inflammation.
Positive_regulation (required) of Positive_regulation (activation) of NPY associated with inflammation and neurogenic inflammation
2) Confidence 0.48 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15499082 Disease Relevance 0.71 Pain Relevance 0.26
In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.
Positive_regulation (cause) of Positive_regulation (elevation) of NPY in plasma
3) Confidence 0.36 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.16 Pain Relevance 0
Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.
Positive_regulation (necessary) of Positive_regulation (induction) of NPY in plasma associated with diabetes mellitus
4) Confidence 0.34 Published 2003 Journal BMC Physiol Section Abstract Doc Link PMC179893 Disease Relevance 0.85 Pain Relevance 0
A large proportion of NPY neurones in the rat hypothalamus express mc3r mRNA while a much lower number of NPY neurones express mc4r mRNA, suggesting that POMC neurones may directly modulate the activity of the hypothalamic NPY system too, mainly through activation of MC3R [61].
Positive_regulation (neurones) of Positive_regulation (proportion) of NPY in hypothalamus
5) Confidence 0.31 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.40 Pain Relevance 0.28
Neuronal migrations towards the cortex and basal ganglia were greatly reduced in mutants, causing a periventricular accumulation of NPY+ (neuropeptide Y) or calretinin+ neurons in the MGE.
Positive_regulation (causing) of Positive_regulation (accumulation) of NPY in neurons associated with neuropeptide
6) Confidence 0.23 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0.12 Pain Relevance 0.29

General Comments

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