INT122474

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.71
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) signal transduction (Npy1r) plasma membrane (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
synaptic cleft 1
Npy1r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 23 97.52 Very High Very High Very High
Inflammation 5 97.12 Very High Very High Very High
adenocard 92 96.96 Very High Very High Very High
Hippocampus 27 96.00 Very High Very High Very High
gABA 15 93.44 High High
Neuropeptide 16 92.92 High High
cerebral cortex 3 86.20 High High
Peripheral nervous system 1 83.48 Quite High
agonist 28 82.40 Quite High
depression 3 72.76 Quite High
Disease Link Frequency Relevance Heat
Colitis 4 99.52 Very High Very High Very High
Targeted Disruption 4 99.06 Very High Very High Very High
Neurogenic Inflammation 2 97.12 Very High Very High Very High
Cognitive Disorder 1 94.32 High High
Nociception 1 88.52 High High
Autism 50 87.20 High High
Disease 11 79.20 Quite High
Depression 3 72.76 Quite High
Weight Loss 1 70.40 Quite High
Diarrhoea 1 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regarding the desensitization of A1Rs but not of Y1Rs, this may be important under pathophysiological conditions with increased adenosine concentration in the synaptic cleft.
Neg (not) Negative_regulation (desensitization) of Y1R in synaptic cleft associated with adenocard
1) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.12 Pain Relevance 0.37
Thorsell et al. [33] reported impaired spatial learning in transgenic rats that over expressed NPY and demonstrated decreased NPY Y1 receptor binding.
Negative_regulation (decreased) of NPY Y1 receptor associated with targeted disruption
2) Confidence 0.37 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.61 Pain Relevance 0.41
Because neurogenic inflammation could participate in colitis, the aim of this study was to investigate the role of the NPY Y1 receptor in acute colitis using mice genetically deficient of NPY Y1 receptor.
Negative_regulation (deficient) of Y1 receptor associated with colitis, inflammation and neurogenic inflammation
3) Confidence 0.37 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15499082 Disease Relevance 0.97 Pain Relevance 0.33

General Comments

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