INT122480

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.75
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1, PLAU) extracellular region (SERPINE1, PLAU) plasma membrane (SERPINE1, PLAU)
peptidase activity (PLAU) signal transduction (PLAU)
SERPINE1 (Homo sapiens)
PLAU (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 61.12 Quite High
methotrexate 2 28.72 Quite Low
palliative 4 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 80 99.68 Very High Very High Very High
Breast Cancer 68 99.52 Very High Very High Very High
Disease 18 98.80 Very High Very High Very High
Aggression 4 98.48 Very High Very High Very High
Metastasis 50 75.64 Quite High
Head & Neck Cancer 3 75.00 Quite High
Pain 2 61.12 Quite High
Skin Cancer 47 53.60 Quite High
Recurrence 20 35.40 Quite Low
Alzheimer's Dementia 1 19.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Numerous research groups have demonstrated that the antigen content of uPA and PAI-1 in primary breast cancer tissue correlates with disease aggressiveness and has a strong prognostic impact on primary breast cancer [1-6,21,22].
PAI-1 Binding (content) of uPA associated with aggression, breast cancer and disease
1) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.83 Pain Relevance 0
Several international research groups have demonstrated that the protein content of uPA and PAI-1 in the tumor correlates with disease aggressiveness and has a strong prognostic impact on disease-free survival and overall survival in patients with primary breast cancer [1-6].
PAI-1 Binding (content) of uPA associated with cancer, breast cancer, aggression and disease
2) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.90 Pain Relevance 0
In combination with other ECM proteins found in our analysis, PAI-1 and uPA, the association with DFI and OS became even more significant (p < 0.001).
PAI-1 Binding (association) of uPA
3) Confidence 0.08 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499618 Disease Relevance 0.51 Pain Relevance 0.06
Several other proteins, fibrin, uPA receptor (uPAR), and two main PA inhibitors, PAI-1 and PAI-2, are also important in this process.
PAI-1 Binding (receptor) of uPA
4) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.51 Pain Relevance 0

General Comments

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