INT122487

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 17.88
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
macrophages 2
cleavage 2
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 98.80 Very High Very High Very High
Inflammation 143 97.36 Very High Very High Very High
cytokine 69 96.20 Very High Very High Very High
antagonist 23 94.96 High High
medulla 20 94.72 High High
Spinal cord 32 93.60 High High
Hippocampus 9 83.56 Quite High
Central nervous system 12 72.24 Quite High
COX-2 inhibitor 156 67.60 Quite High
cINOD 57 62.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1008 100.00 Very High Very High Very High
Death 272 99.68 Very High Very High Very High
Chronic Lymphoid Leukemia 14 98.08 Very High Very High Very High
INFLAMMATION 154 97.36 Very High Very High Very High
Stress 107 96.24 Very High Very High Very High
Shock 11 93.76 High High
Disease 163 93.40 High High
Lymphatic System Cancer 39 92.68 High High
Rabies Virus Infection 61 92.40 High High
Cancer 696 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There, cytochrome c forms a complex with Apaf-1, leading to activation of caspase-9 that, in turn, activates executioner caspases such as caspase-3, -6, and -7, which are instrumental in the induction of apoptosis (19, 24).
Positive_regulation (leading) of Positive_regulation (activation) of caspase-9 associated with apoptosis
1) Confidence 0.67 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.08 Pain Relevance 0
Cytosolic CytC is required for the formation of the apoptosome and the resulting activation of procaspase-9 which in turn cleaves and activates the downstream effecter caspase-3 which then leads to eventual cell apoptosis [32, 33].
Positive_regulation (required) of Positive_regulation (activation) of caspase-9 associated with apoptosis
2) Confidence 0.49 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.76 Pain Relevance 0
Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-9 in cleavage associated with apoptosis
3) Confidence 0.40 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.35 Pain Relevance 0.12
It led to an increase in cytosolic Ca(2+), calpain activation, loss of the mitochondrial transmembrane potential, release of mitochondrial cytochrome c, and caspase-9 and -7 activation.
Positive_regulation (increase) of Positive_regulation (activation) of caspase-9
4) Confidence 0.25 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.82
The intrinsic pathway is triggered by mitochondrial death signals, which lead to the activation of caspase-9.
Positive_regulation (lead) of Positive_regulation (activation) of caspase-9 associated with death
5) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.88 Pain Relevance 0.12
Moreover, the GSH depletion that we observed leads to cytochrome c release and caspase-9 induction [28].
Positive_regulation (leads) of Positive_regulation (induction) of caspase-9
6) Confidence 0.23 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.02 Pain Relevance 0.07
Apoptosis or programmed cell death can be induced by multiple insults which proceeds through the mitochondrial pathway – mitochondrial outer membrane permeabilization (MOMP) in which cytochrome c appears to be a major inducer of the entire cascade though the activation of caspase-9 and -3 [12].
Positive_regulation (inducer) of Positive_regulation (activation) of caspase-9 associated with apoptosis
7) Confidence 0.20 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1310615 Disease Relevance 1.52 Pain Relevance 0.40
Bromelain treatment induces up-regulation of p53 and Bax and subsequent activation of caspase-3 and caspase-9 with a decrease in Bcl-2 expression [154].
Positive_regulation (induces) of Positive_regulation (activation) of caspase-9
8) Confidence 0.09 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.70 Pain Relevance 0.09
the activation of caspase-8, but not caspase-9, indicating the involvement of a
Neg (not) Positive_regulation (not) of Positive_regulation (activation) of caspase-9
9) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.50 Pain Relevance 0
Our results support this notion where both procaspase-9 and the active caspase-9 were significantly increased in the Pa-PDT treated R-HepG2 cells, and finally trigger the activation of procaspase-3 that was started to be cleaved at 2 h after the Pa-PDT treatment (Figure 5A).
Positive_regulation (increased) of Positive_regulation (increased) of caspase-9
10) Confidence 0.08 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.71 Pain Relevance 0
One is the direct activation of caspase-3 by caspase 8, and the other is the activation of caspase-9, also a direct activator of caspase 3, through the mitochondrial pathway.
Positive_regulation (activation) of Positive_regulation (activator) of caspase-9
11) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.58 Pain Relevance 0
-actin, H2O2 treatment alone showed a slight decrease in the level of Bcl-2 to 0.95 fold of control but a large increase in the level of tBid, Apaf-1 and cytosolic CytC, the coactivators of apoptosome for the activation of caspase-9, to 4.81, 1.06, and 1.75 fold of control, respectively.
Positive_regulation (increase) of Positive_regulation (activation) of caspase-9
12) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.29 Pain Relevance 0
Caspase 9 activation promotes the activation of caspases 3, 6, and 7, leading to rapid cell death.
Positive_regulation (activation) of Positive_regulation (activation) of Caspase 9 associated with death
13) Confidence 0.06 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.86 Pain Relevance 0
The extrinsic apoptotic pathway can activate the intrinsic pathway via truncation of the BH3-only protein Bid (t-Bid) by caspase-8. t-Bid interacts with mitochondria, by favoring the activation of the proapoptotic Bcl-2 family members Bak and Bax, thus leading to MOMP and caspase-9 activation [51, 95] (Figure 4).
Positive_regulation (leading) of Positive_regulation (activation) of caspase-9 associated with apoptosis
14) Confidence 0.06 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.46 Pain Relevance 0.03
The extrinsic apoptotic pathway can activate the intrinsic pathway via truncation of the BH3-only protein Bid (t-Bid) by caspase-8. t-Bid interacts with mitochondria, by favoring the activation of the proapoptotic Bcl-2 family members Bak and Bax, thus leading to MOMP and caspase-9 activation [51, 95] (Figure 4).
Positive_regulation (activation) of Positive_regulation (activation) of caspase-9 associated with apoptosis
15) Confidence 0.06 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.50 Pain Relevance 0.04
Biochemical analysis confirmed that while macrophages inhibited TRAIL-induced activation of caspase 8 and caspase-9 and cleavage of PARP and ?
Positive_regulation (induced) of Positive_regulation (activation) of caspase-9 in macrophages
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.14 Pain Relevance 0
The intrinsic or "mitochondrial" pathway, instead, includes the activation of the initiator caspase-9 mediated by the heptameric apoptosome complex.
Positive_regulation (mediated) of Positive_regulation (activation) of caspase-9
17) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.39 Pain Relevance 0.10
Exposure of HepG2 cells to DLS resulted in a dose-dependent activation of caspase3, caspase9 and caspase8 (Fig. 3a, b), which indicated the activation of both the intrinsic and extrinsic apoptosis pathways.
Positive_regulation (resulted) of Positive_regulation (activation) of caspase9 associated with apoptosis
18) Confidence 0.01 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.91 Pain Relevance 0

General Comments

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