INT122488

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 8.64
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP9) peptidase activity (CASP9) nucleus (CASP9)
intracellular (CASP9)
Anatomy Link Frequency
cleavage 7
macrophages 1
CASP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.82 Very High Very High Very High
cINOD 16 92.28 High High
COX-2 inhibitor 8 87.24 High High
COX2 3 25.00 Low Low
cOX1 1 25.00 Low Low
agonist 28 5.00 Very Low Very Low Very Low
antagonist 24 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 282 99.72 Very High Very High Very High
Hepatocellular Cancer 8 98.78 Very High Very High Very High
Lung Cancer 10 95.96 Very High Very High Very High
Cancer 214 90.96 High High
Death 46 90.88 High High
Colon Cancer 60 86.28 High High
Pancreatic Cancer 21 84.80 Quite High
INFLAMMATION 11 84.16 Quite High
Stress 5 80.92 Quite High
Aggression 2 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coadministration of sulindac sulfide and the small-molecule Bcl-2 inhibitor HA14-1 increased apoptosis induction and enhanced caspase-8 and caspase-9 cleavage, Bax redistribution, and cytochrome c and second mitochondria-derived activator of caspase release.
Protein_catabolism (cleavage) of caspase-9 in cleavage associated with apoptosis
1) Confidence 0.46 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.35 Pain Relevance 0.14
In HuH-6 hepatoma cells the combination-induced apoptosis was associated with caspase-9 and -3 activation, PARP cleavage, release of cytochrome c from the mitochondria into the cytosol and down-regulation of survivin and beta-catenin levels.
Protein_catabolism (cleavage) of caspase-9 in cleavage associated with hepatocellular cancer and apoptosis
2) Confidence 0.42 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.78 Pain Relevance 0.50
The dose-dependent proteolytic cleavage of caspase-9 was detected.
Protein_catabolism (cleavage) of caspase-9 in cleavage
3) Confidence 0.37 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.75 Pain Relevance 0
The combined nimesulide-radiation treatment increased apoptosis, induced the cleavage of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP), activated caspase-8, and induced cleavage of Bid.
Protein_catabolism (cleavage) of caspase-9 in cleavage associated with apoptosis
4) Confidence 0.31 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.59 Pain Relevance 0.30
Derivatives induced apoptosis was mediated by the cleavage and activation of caspase-9 and caspase-3, but not caspase 8, implicating the mitochondrial pathway for apoptosis induction.
Protein_catabolism (cleavage) of caspase-9 in cleavage associated with apoptosis
5) Confidence 0.23 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.33 Pain Relevance 0.12
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Protein_catabolism (cleavage) of caspase-9 in cleavage associated with qutenza
6) Confidence 0.21 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.09 Pain Relevance 0.75
Biochemical analysis confirmed that while macrophages inhibited TRAIL-induced activation of caspase 8 and caspase-9 and cleavage of PARP and ?
Protein_catabolism (cleavage) of caspase-9 in macrophages
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.13 Pain Relevance 0
mitochondria and subsequent caspase-9 cleavage or activation.
Protein_catabolism (cleavage) of caspase-9 in cleavage
8) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.61 Pain Relevance 0

General Comments

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