INT1225

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Context Info
Confidence 0.30
First Reported 1976
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 1.05
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Snai1) cytoplasm (Snai1)
Anatomy Link Frequency
Sympathetic 3
nerve 2
sinus 1
nitrergic neurons 1
Snai1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 12 100.00 Very High Very High Very High
anesthesia 9 99.84 Very High Very High Very High
medulla 2 99.56 Very High Very High Very High
Rostral ventrolateral medulla 15 99.18 Very High Very High Very High
Catecholamine 7 99.06 Very High Very High Very High
narcan 16 98.88 Very High Very High Very High
withdrawal 6 94.68 High High
addiction 1 85.84 High High
Spinal cord 1 83.32 Quite High
Dopamine 2 75.96 Quite High
Disease Link Frequency Relevance Heat
Hypertension 16 99.58 Very High Very High Very High
Sprains And Strains 3 98.84 Very High Very High Very High
Pressure Volume 2 Under Development 1 67.84 Quite High
Heart Rate Under Development 1 66.56 Quite High
Pressure And Volume Under Development 3 30.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that high levels of circulating ANG II did not attenuate the response range of open-loop carotid sinus baroreflex control for AP, SNA or HR in anesthetized and vagotomized rats.
Regulation (control) of SNA in sinus
1) Confidence 0.30 Published 2009 Journal J Physiol Sci Section Abstract Doc Link 19688237 Disease Relevance 0 Pain Relevance 0
To examine whether feedforward control by central command activates preganglionic adrenal sympathetic nerve activity (AdSNA) and releases catecholamines from the adrenal medulla, we investigated the effects of electrical stimulation of the hypothalamic locomotor region on preganglionic AdSNA and secretion rate of adrenal catecholamines in anaesthetized rats.
Spec (investigated) Regulation (effects) of AdSNA in nerve associated with medulla and catecholamine
2) Confidence 0.24 Published 2010 Journal Exp. Physiol. Section Abstract Doc Link 19700518 Disease Relevance 0 Pain Relevance 0.19
The aim of this study was to examine the effect of i.v. morphine on sympathetic nerve activity (SNA) in the rat.
Spec (examine) Regulation (effect) of SNA in nerve associated with morphine
3) Confidence 0.24 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2160005 Disease Relevance 0.13 Pain Relevance 0.25
Mean arterial pressure (MAP) and SNA were not significantly affected by anesthesia with low doses of pentobarbital (20-25 mg/kg).
Neg (not) Regulation (affected) of SNA associated with anesthesia
4) Confidence 0.24 Published 1976 Journal Circ. Res. Section Abstract Doc Link 178466 Disease Relevance 0.27 Pain Relevance 0.10
Sympathetic nerve activity (SNA) and high pressure baroreceptor regulation of SNA were studied in the Okamoto strain of spontaneously hypertensive rat (SHR).
Regulation (regulation) of SNA in Sympathetic associated with hypertension and sprains and strains
5) Confidence 0.24 Published 1976 Journal Circ. Res. Section Abstract Doc Link 178466 Disease Relevance 0.27 Pain Relevance 0.09
Sympathetic nerve activity (SNA) and high pressure baroreceptor regulation of SNA were studied in the Okamoto strain of spontaneously hypertensive rat (SHR).
Regulation (regulation) of SNA in Sympathetic associated with hypertension and sprains and strains
6) Confidence 0.24 Published 1976 Journal Circ. Res. Section Abstract Doc Link 178466 Disease Relevance 0.27 Pain Relevance 0.09
The data suggest that nitrergic neurons within the PVN and, to a lesser extent, in the NTS, some of which project to the RVLM, may contribute to the central pathways influencing SNA elicited by cardiac mechanoreceptor stimulation.
Regulation (influencing) of SNA in nitrergic neurons associated with rostral ventrolateral medulla
7) Confidence 0.23 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16682470 Disease Relevance 0 Pain Relevance 0.33
Recent reports from our laboratory show that these pathways 1) are activated following cardiac mechanoreceptor stimulation, and 2) produce nitric oxide, known to influence SNA.
Regulation (influence) of SNA
8) Confidence 0.23 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16682470 Disease Relevance 0 Pain Relevance 0.29
The aim of the study was to examine regional changes in sympathetic nerve activity (SNA) and baroreceptor function and arterial plasma catecholamines, arginine vasopressin (AVP) and plasma renin activity during morphine withdrawal in chloralose-anesthetized rats.
Spec (examine) Regulation (changes) of SNA in sympathetic associated with catecholamine, withdrawal and morphine
9) Confidence 0.22 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2187076 Disease Relevance 0 Pain Relevance 0.60
The maximum gain was not affected for AP (1.57 +/- 0.28 vs. 1.20 +/- 0.25), SNA (1.94 +/- 0.34 vs. 2.04 +/- 0.42%/mmHg) or HR (1.11 +/- 0.12 vs. 1.28 +/- 0.19 beats min(-1) mmHg(-1)).
Neg (not) Regulation (affected) of SNA
10) Confidence 0.18 Published 2009 Journal J Physiol Sci Section Abstract Doc Link 19688237 Disease Relevance 0 Pain Relevance 0
The higher naloxone doses exacerbated the hypertension without any further changes in rSNA or in behaviour.
Neg (without) Regulation (changes) of rSNA associated with hypertension and narcan
11) Confidence 0.14 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3250217 Disease Relevance 0.10 Pain Relevance 0.56
Resting SNA was not detectably altered, but the baroreflex range and gain were reduced approximately 40% (P < 0.05).
Neg (not) Regulation (altered) of SNA
12) Confidence 0.10 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10938264 Disease Relevance 0 Pain Relevance 0.22

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