INT12250

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 6.90
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
liver 3
B12 3
grey matter 2
optic 2
Plasma 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
Dynorphin 3 99.88 Very High Very High Very High
Multiple sclerosis 15 99.80 Very High Very High Very High
Neuritis 23 99.12 Very High Very High Very High
Demyelination 39 98.92 Very High Very High Very High
midbrain 4 98.32 Very High Very High Very High
imagery 117 97.84 Very High Very High Very High
medulla 6 97.56 Very High Very High Very High
Glutamate 4 96.48 Very High Very High Very High
alcohol 18 94.24 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 61 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 99.68 Very High Very High Very High
Optic Neuritis 23 99.12 Very High Very High Very High
Hepatotoxicity 6 98.20 Very High Very High Very High
Cerebrovascular Disease 1 96.92 Very High Very High Very High
Hypoxia 8 96.80 Very High Very High Very High
Oxidative Phosphorylation Disease 50 95.84 Very High Very High Very High
Hyperhomocysteinemia 1 93.80 High High
Syndrome 4 91.56 High High
Obesity 1 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Occipital cortex and whole brain analysis comparing all optic neuritis patients and controls revealed a selective decrease of MTR bilaterally in the visual cortex in patients [Brodmann area (BA) 17].
Negative_regulation (decrease) of MTR in optic associated with optic neuritis and neuritis
1) Confidence 0.50 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.66 Pain Relevance 0.38
One potential mechanism for the decreased grey matter MTR (GM MTR) observed is trans-synaptic morphological abnormality secondary to demyelinating lesions that are in an anatomically linked pathway but remote location.
Negative_regulation (decreased) of MTR in grey matter associated with demyelinating disease
2) Confidence 0.43 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.57 Pain Relevance 0.25
One potential mechanism for the decreased grey matter MTR (GM MTR) observed is trans-synaptic morphological abnormality secondary to demyelinating lesions that are in an anatomically linked pathway but remote location.
Negative_regulation (decreased) of MTR in grey matter associated with demyelinating disease
3) Confidence 0.43 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.57 Pain Relevance 0.25
The intrinsic MTR decrease seen in patients suggests that there are structural changes in the visual cortex following an attack of optic neuritis.
Negative_regulation (decrease) of MTR in optic associated with optic neuritis and neuritis
4) Confidence 0.37 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.60 Pain Relevance 0.44
In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination.
Negative_regulation (reductions) of MTR associated with demyelination and multiple sclerosis
5) Confidence 0.37 Published 2004 Journal Brain Section Abstract Doc Link 14736754 Disease Relevance 0.50 Pain Relevance 0.40
Nitrous oxide inhibits methionine synthase, which aids in the conversion of homocysteine to methionine.
Negative_regulation (inhibits) of methionine synthase associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.35 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9728858 Disease Relevance 0.29 Pain Relevance 0.13
Influence of vitamin B12 status on the inactivation of methionine synthase by nitrous oxide.
Negative_regulation (inactivation) of methionine synthase in B12
7) Confidence 0.30 Published 1992 Journal Br J Anaesth Section Title Doc Link 1637609 Disease Relevance 0 Pain Relevance 0.09
In contrast, 21-day-old pups demonstrated a decrease in methionine-enkephalin concentration in three of the four nuclei studied when exposed to intermittent hypoxia, as well as an apparent ability to recover from an acute hypoxic exposure (p less than 0.05).
Negative_regulation (decrease) of methionine-enkephalin associated with hypoxia and enkephalin
8) Confidence 0.26 Published 1986 Journal Pediatr. Res. Section Abstract Doc Link 3725463 Disease Relevance 0.57 Pain Relevance 0.66
We have studied the influence of maternal serum B12 concentration on the inactivation of placental methionine synthase activity by nitrous oxide in an obstetric population.
Negative_regulation (inactivation) of methionine synthase in B12
9) Confidence 0.26 Published 1992 Journal Br J Anaesth Section Abstract Doc Link 1637609 Disease Relevance 0 Pain Relevance 0.09
MTR was reduced in affected nerves compared to both clinically unaffected nerves from patients and control nerves (P < 0.001).
Negative_regulation (reduced) of MTR in nerves
10) Confidence 0.24 Published 2007 Journal Mult. Scler. Section Abstract Doc Link 17468442 Disease Relevance 0.39 Pain Relevance 0.42
CONCLUSIONS: The inactivation of methionine synthase and L methylmalonylcoA mutase by nitrous oxide has been previously demonstrated.
Negative_regulation (inactivation) of methionine synthase
11) Confidence 0.17 Published 2007 Journal Rev. Neurol. (Paris) Section Body Doc Link 17404524 Disease Relevance 0.08 Pain Relevance 0
It has been extensively documented that in vivo inhibition of methionine synthase induced by ethanol plays a critical role in hepatotoxicity and the administration of ethanol depletes hepatic S-adenosylmethionine which protects the liver from ethanol-induced fatty infiltration (Barak et al., 2001; Barak et al., 2003).
Negative_regulation (inhibition) of methionine synthase in liver associated with hepatotoxicity
12) Confidence 0.11 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.10 Pain Relevance 0.05
In vitro study with rat liver methionine synthase has demonstrated that inactivation of methionine synthase was induced by acetaldehyde and ethanol did not inhibit methionine synthase directly (12) (Kenyon et al., 1998).
Negative_regulation (inactivation) of methionine synthase in liver
13) Confidence 0.11 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.09 Pain Relevance 0.04
In vitro study with rat liver methionine synthase has demonstrated that inactivation of methionine synthase was induced by acetaldehyde and ethanol did not inhibit methionine synthase directly (12) (Kenyon et al., 1998).
Negative_regulation (inhibit) of methionine synthase in liver
14) Confidence 0.09 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788200 Disease Relevance 0.09 Pain Relevance 0.04
Methionine-enkephalin (MET) was lowered in duodenum by 28%.
Negative_regulation (lowered) of Methionine-enkephalin in duodenum associated with enkephalin
15) Confidence 0.08 Published 1988 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 3418013 Disease Relevance 0 Pain Relevance 0.57
Plasma 5-methyl-tetrahydrofolate concentrations increased uniformly by 20% after nitrous oxide anesthesia, indicating the inactivation of methionine synthase and subsequent folate trapping.
Negative_regulation (inactivation) of methionine synthase in Plasma
16) Confidence 0.03 Published 2008 Journal Anesthesiology Section Body Doc Link 18580170 Disease Relevance 0 Pain Relevance 0
While the loss of TH following GMA-MS was transient, a sustained loss (34%) was observed in the midbrain 105 days after cessation of MMA-HS exposure.
Negative_regulation (loss) of GMA-MS in midbrain associated with midbrain
17) Confidence 0.03 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.57 Pain Relevance 0.33
Nitrous oxide (N2O) oxidizes vitamin B12 and thus decreases DNA production by inactivation of methionine synthase.
Negative_regulation (inactivation) of methionine synthase in B12
18) Confidence 0.02 Published 1995 Journal Gesundheitswesen Section Abstract Doc Link 7719049 Disease Relevance 0 Pain Relevance 0.07
The MTR in the white matter of our patients was decreased, indicating a reduced capacity of the macromolecule-bound protons in brain tissue to exchange magnetization with the surrounding protons in free water, probably reflecting lack of myelin and damage of axonal membranes.
Negative_regulation (decreased) of MTR in brain
19) Confidence 0.01 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.97 Pain Relevance 0.05
High values of ADC were observed, and both FA and MTR were attenuated.


Negative_regulation (attenuated) of MTR
20) Confidence 0.01 Published 2009 Journal Neuroradiology Section Abstract Doc Link PMC2744817 Disease Relevance 0.59 Pain Relevance 0.56

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