INT122547

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.10
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
hippocampus 3
striatum 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 46 99.30 Very High Very High Very High
Hippocampus 6 98.32 Very High Very High Very High
fluoxetine 4 96.48 Very High Very High Very High
antidepressant 8 96.26 Very High Very High Very High
sSRI 6 95.96 Very High Very High Very High
Angina 31 90.76 High High
Nicotine 2 83.88 Quite High
Serotonin 2 38.96 Quite Low
imagery 4 26.28 Quite Low
ischemia 4 11.84 Low Low
Disease Link Frequency Relevance Heat
Atherosclerosis 21 100.00 Very High Very High Very High
Depression 56 99.30 Very High Very High Very High
Cv General 3 Under Development 27 90.76 High High
Myocardial Infarction 2 89.44 High High
Schizophrenia 4 88.88 High High
Stable Angina Pectoris 3 84.24 Quite High
Cognitive Disorder 4 82.40 Quite High
Coronary Artery Disease 73 78.76 Quite High
Diabetic Retinopathy 1 75.92 Quite High
Manic Depressive Disorder 18 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGF-2 activity for IL-6 induction was the same as that of IL-17.
Positive_regulation (activity) of Positive_regulation (induction) of FGF-2
1) Confidence 0.44 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (led) of Positive_regulation (increased) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
2) Confidence 0.44 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62
The high level of serum VEGF and bFGF reported in other stages of atherosclerosis should be accredited to other potential sites of production like the atherosclerotic lesion itself.
Positive_regulation (accredited) of Positive_regulation (level) of bFGF associated with atherosclerosis
3) Confidence 0.43 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.25 Pain Relevance 0.26
Moreover, recent work in rats has shown that a combination of the SSRI antidepressant fluoxetine and the atypical antipsychotic drug olanzapine, which appear in human studies to be more effective for the treatment of resistant depression in combination than individually, led to increased levels of FGF2 mRNA in prefrontal cortex, as well as in hippocampus and striatum [8].
Positive_regulation (led) of in striatum Positive_regulation (increased) of FGF2 in hippocampus associated with antidepressant, depression, hippocampus, ssri and fluoxetine
4) Confidence 0.15 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.92 Pain Relevance 0.62

General Comments

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