INT122548

Context Info Confidence 0.41 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.01 Pain Relevance 0.22

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2) nucleus (FGF2) cytoplasm (FGF2)

Anatomy Link Frequency anterior 2 FaDu 2 FGF2 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 56 99.96 COX-2 inhibitor 6 89.04 Arthritis 12 51.28 metalloproteinase 13 44.32 cytokine 13 34.96 Inflammation 24 34.56 Pain 7 5.00 fibrosis 3 5.00 Inflammatory response 3 5.00 corticosteroid 2 5.00

Disease Link Frequency Relevance Heat Frailty 58 99.96 Cancer 63 99.84 Carcinoma 12 78.44 Osteophyte 1 59.16 Arthritis 16 51.28 Disease 10 49.08 INFLAMMATION 26 34.56 Syndrome 1 27.60 Fibrosis 5 26.72 Apoptosis 17 24.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

FGF-2 rapidly induced activation of ERK1/2 and p38 MAP kinases, and specific inhibitors for these enzymes significantly reduced FGF-2-induced IL-6 release.

Negative_regulation (reduced) of Localization (release) of FGF-2

1) Confidence 0.41 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0

Triple medication was neither for FaDu nor for HeLa cells more effective than Celecoxib® alone, pinpointing that COX-2 inhibition was instrumental in the reduction of bFGF release by tumour cells.

Negative_regulation (reduction) of Localization (release) of bFGF in FaDu associated with cancer

2) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.60 Pain Relevance 0.04

In a rabbit anterior cruciate ligament transection model, however, sustained release formulations of FGF-2 reduced OA severity [81].

Negative_regulation (reduced) of Localization (release) of FGF-2 in anterior associated with osteoarthritis

3) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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