INT122548

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
anterior 2
FaDu 2
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 56 99.96 Very High Very High Very High
COX-2 inhibitor 6 89.04 High High
Arthritis 12 51.28 Quite High
metalloproteinase 13 44.32 Quite Low
cytokine 13 34.96 Quite Low
Inflammation 24 34.56 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 58 99.96 Very High Very High Very High
Cancer 63 99.84 Very High Very High Very High
Carcinoma 12 78.44 Quite High
Osteophyte 1 59.16 Quite High
Arthritis 16 51.28 Quite High
Disease 10 49.08 Quite Low
INFLAMMATION 26 34.56 Quite Low
Syndrome 1 27.60 Quite Low
Fibrosis 5 26.72 Quite Low
Apoptosis 17 24.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGF-2 rapidly induced activation of ERK1/2 and p38 MAP kinases, and specific inhibitors for these enzymes significantly reduced FGF-2-induced IL-6 release.
Negative_regulation (reduced) of Localization (release) of FGF-2
1) Confidence 0.41 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Triple medication was neither for FaDu nor for HeLa cells more effective than Celecoxib® alone, pinpointing that COX-2 inhibition was instrumental in the reduction of bFGF release by tumour cells.
Negative_regulation (reduction) of Localization (release) of bFGF in FaDu associated with cancer
2) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.60 Pain Relevance 0.04
In a rabbit anterior cruciate ligament transection model, however, sustained release formulations of FGF-2 reduced OA severity [81].
Negative_regulation (reduced) of Localization (release) of FGF-2 in anterior associated with osteoarthritis
3) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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