INT122561

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 14.02
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
adipose tissue 8
visceral 2
platelet 2
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 1 98.84 Very High Very High Very High
cytokine 9 96.76 Very High Very High Very High
Pain 2 94.96 High High
Central grey 1 93.56 High High
central sensitization 2 90.28 High High
tolerance 49 86.64 High High
Migraine 7 86.44 High High
Calcitonin gene-related peptide 1 82.96 Quite High
Inflammation 32 82.56 Quite High
Angina 11 79.16 Quite High
Disease Link Frequency Relevance Heat
Obesity 153 100.00 Very High Very High Very High
Sleep Disorders 60 100.00 Very High Very High Very High
Atherosclerosis 13 99.92 Very High Very High Very High
Insulin Resistance 70 99.72 Very High Very High Very High
Diabetes Mellitus 219 99.62 Very High Very High Very High
Neuropathic Pain 2 99.52 Very High Very High Very High
Hyperlipidemia 5 99.38 Very High Very High Very High
Increased Venous Pressure Under Development 11 98.96 Very High Very High Very High
Coronary Artery Disease 41 98.84 Very High Very High Very High
Headache 7 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our data showed, as a whole, that sleep deprivation leads to a significant decrease in adiponectin gene expression, which cannot be prevented by a rich fish oil diet.
Negative_regulation (decrease) of Gene_expression (expression) of adiponectin associated with sleep disorders
1) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.69 Pain Relevance 0
Adiponectin expression and serum levels decrease with obesity and are positively associated with weigh loss [58].
Negative_regulation (decrease) of Gene_expression (expression) of Adiponectin associated with obesity
2) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.49 Pain Relevance 0.03
Dietary fish oil did not prevent sleep deprived rats from a reduction in adipose tissue adiponectin gene expression

Sleep deprivation in humans has been related to weight gain and consequently, increased risk for insulin resistance.

Negative_regulation (deprivation) of Gene_expression (expression) of adiponectin in adipose tissue associated with obesity, insulin resistance, weight gain and sleep disorders
3) Confidence 0.56 Published 2008 Journal Lipids Health Dis Section Title Doc Link PMC2613381 Disease Relevance 0.88 Pain Relevance 0.08
Studies have shown that adiponectin expression is decreased in obese subjects and those with metabolic syndrome or diabetes mellitus.
Negative_regulation (decreased) of Gene_expression (expression) of adiponectin associated with diabetes mellitus, obesity and metabolic syndrome
4) Confidence 0.53 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17651832 Disease Relevance 0.96 Pain Relevance 0.32
The major finding of the present study was the reduction in adiponectin retroperitoneal adipose tissue gene expression in PSD rats when compared to control rats, not accompanied by alterations in epididymal adipose tissue for adiponectin and TNF-?
Negative_regulation (reduction) of Gene_expression (expression) of adiponectin in adipose tissue associated with obesity
5) Confidence 0.49 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.53 Pain Relevance 0.14
The Duncan test showed that adiponectin gene expression in retroperitoneal adipose tissue was significantly lower in PSD rats compared with CTRL rats (p < 0.004), as shown in Fig. 6A.
Negative_regulation (lower) of Gene_expression (expression) of adiponectin in adipose tissue associated with obesity
6) Confidence 0.41 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.54 Pain Relevance 0.06
Furthermore, the levels of adiponectin are decreased in obesity.
Negative_regulation (decreased) of Gene_expression (levels) of adiponectin associated with obesity
7) Confidence 0.26 Published 2007 Journal Neurology Section Abstract Doc Link 17515549 Disease Relevance 1.67 Pain Relevance 1.04
At baseline, FMD (1.9 compared with 3.2%; P=0.22) and CRP levels (6.95 compared with. 5.51 mg/l; P=0.40) did not differ between Type II diabetic and non-diabetic patients, whereas adiponectin levels were lower in Type II diabetic patients (2.8 compared with 5.0 ng/ml; P<0.05).
Negative_regulation (lower) of Gene_expression (levels) of adiponectin associated with diabetes mellitus
8) Confidence 0.21 Published 2005 Journal Clin. Sci. Section Abstract Doc Link 15504106 Disease Relevance 1.87 Pain Relevance 0.13
The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional laboratory parameters and markers of platelet activation.
Negative_regulation (evaluate) of Gene_expression (levels) of adiponectin in platelet associated with coronary artery disease
9) Confidence 0.18 Published 2010 Journal Platelets Section Abstract Doc Link 19954410 Disease Relevance 0.81 Pain Relevance 0.15
Thus, leptin stimulates expression of proinflammatory mediators while inhibiting the production of the potentially beneficial hormone adiponectin.

3.3.

Negative_regulation (inhibiting) of Gene_expression (production) of adiponectin
10) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.90 Pain Relevance 0.14
Reduced levels of adiponectin, an insulin-sensitizing protein whose secretion by adipose tissue is paradoxically decreased in obesity, may also contribute to insulin resistance and DCM.115 Indeed, in a recent study, central obesity, as part of the MetS, was significantly and independently associated with LV myocardial dysfunction.116

The effect of diabetic nephropathy

Negative_regulation (Reduced) of Gene_expression (levels) of adiponectin in adipose tissue associated with cardiomyopathy, abdominal obesity, obesity, diabetic cardiomyopathies, metabolic syndrome, insulin resistance and diabetic nephropathy
11) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 2.84 Pain Relevance 0.05
Treatment of diabetic men with T has many beneficial effects, including increasing insulin sensitivity, correcting abnormalities in lipid metabolism, especially hypertriglyceridaemia, reducing visceral adiposity, decreasing leptin and adiponectin levels, reversing neuropathy, and improving erectile function.
Negative_regulation (decreasing) of Gene_expression (levels) of adiponectin in visceral associated with congenital anomalies, diabetes mellitus, neuropathic pain and hyperlipidemia
12) Confidence 0.06 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 1.65 Pain Relevance 0.13

General Comments

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