INT122567

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 10.18
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mog)
Anatomy Link Frequency
oligodendrocyte 4
leukocyte 1
brains 1
endothelium 1
T cells 1
Mog (Mus musculus)
Eae1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 92 99.86 Very High Very High Very High
chemokine 82 99.42 Very High Very High Very High
b2 receptor 68 99.28 Very High Very High Very High
Inflammation 104 98.66 Very High Very High Very High
Opioid 4 98.60 Very High Very High Very High
Multiple sclerosis 105 98.56 Very High Very High Very High
Neuritis 22 97.54 Very High Very High Very High
opioid receptor 2 96.32 Very High Very High Very High
antagonist 22 91.80 High High
cytokine 32 90.24 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 569 100.00 Very High Very High Very High
Disease 88 99.80 Very High Very High Very High
Targeted Disruption 20 99.46 Very High Very High Very High
INFLAMMATION 122 98.66 Very High Very High Very High
Optic Neuritis 22 97.54 Very High Very High Very High
Recurrence 4 91.04 High High
Neurodegenerative Disease 2 89.96 High High
Adhesions 52 87.68 High High
Encephalitis 2 84.40 Quite High
Demyelinating Disease 36 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the relationship between optic neuritis (ON) and EAE, we examined the incidence of ON in C57BL/6 (B6) mice immunized with a myelin oligodendrocyte/glycoprotein (MOG)-derived peptide or injected with MOG-specific T cells, which are known to induce EAE.
MOG Positive_regulation (induce) of EAE in T cells associated with multiple sclerosis, optic neuritis and neuritis
1) Confidence 0.31 Published 2004 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 15505056 Disease Relevance 0.83 Pain Relevance 0.41
A mouse model of myelin oligodendrocyte glycoprotein (MOG)-induced EAE was employed in conjunction with daily treatment of LDN (0.1 mg/kg, NTX), HDN (10 mg/kg NTX), or vehicle (saline).
MOG Positive_regulation (induced) of EAE in oligodendrocyte associated with multiple sclerosis
2) Confidence 0.16 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19855075 Disease Relevance 1.20 Pain Relevance 0.65
A mouse model of myelin oligodendrocyte glycoprotein (MOG)-induced EAE was employed in conjunction with daily treatment of LDN (0.1 mg/kg, NTX), HDN (10 mg/kg NTX), or vehicle (saline).
myelin oligodendrocyte glycoprotein Positive_regulation (induced) of EAE in oligodendrocyte associated with multiple sclerosis
3) Confidence 0.16 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19855075 Disease Relevance 1.21 Pain Relevance 0.66
The aim of the present study was to evaluate the relevance of B2 receptors to leukocyte-endothelium interactions in the cerebral microcirculation, and its participation in CNS inflammation in the experimental model of myelin-oligodendrocyte-glycoprotein (MOG)35–55-induced EAE in mice.


MOG Positive_regulation (induced) of EAE in endothelium associated with multiple sclerosis, inflammation and central nervous system
4) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2596102 Disease Relevance 1.43 Pain Relevance 0.58
For example, both CCL2 and CCR2 are expressed in brains of patients with MS [52,53] and deletion of CCR2 leads to an almost complete inhibition of MOG35–55-induced EAE in mice [16].
MOG35 Positive_regulation (induced) of EAE in brains associated with multiple sclerosis
5) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.10 Pain Relevance 0.37
In order to evaluate the role of B2 receptor in the cerebral microvasculature we used wild-type (WT) and kinin B2 receptor knockout (B2-/-) mice subjected to MOG35–55-induced EAE.
MOG35 Positive_regulation (induced) of EAE associated with targeted disruption, multiple sclerosis and b2 receptor
6) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2596102 Disease Relevance 1.56 Pain Relevance 0.58
In the present work, we used B2-deficient mice to assess the potential contribution of kinin receptors for the clinical course of disease, leukocyte recruitment, and modulation of chemokines expression in the CNS after EAE induction by MOG35–55.


MOG35 Positive_regulation (induction) of EAE in leukocyte associated with chemokine, multiple sclerosis, central nervous system and disease
7) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.86 Pain Relevance 0.73
We show that the mean disease onset of myelin oligodendrocyte glycoprotein (MOG)-induced EAE in Olig1?
MOG Positive_regulation (induced) of EAE in oligodendrocyte associated with multiple sclerosis and disease
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947525 Disease Relevance 0.99 Pain Relevance 0.14
We show that the mean disease onset of myelin oligodendrocyte glycoprotein (MOG)-induced EAE in Olig1?
myelin oligodendrocyte glycoprotein Positive_regulation (induced) of EAE in oligodendrocyte associated with multiple sclerosis and disease
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947525 Disease Relevance 1.00 Pain Relevance 0.14

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