INT122569

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 17.15
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
brains 8
aortas 6
fat 4
kidney 4
DLN 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 12 100.00 Very High Very High Very High
Kinase C 131 97.12 Very High Very High Very High
opioid receptor 84 96.76 Very High Very High Very High
Hippocampus 54 96.64 Very High Very High Very High
tolerance 35 96.60 Very High Very High Very High
Dopamine 4 96.48 Very High Very High Very High
cytokine 86 94.80 High High
analgesia 6 93.76 High High
Morphine 77 93.36 High High
Inflammation 217 92.96 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 250 99.84 Very High Very High Very High
Targeted Disruption 417 99.80 Very High Very High Very High
Disease 457 99.74 Very High Very High Very High
Cancer 393 99.24 Very High Very High Very High
Congenital Anomalies 43 98.84 Very High Very High Very High
Obesity 73 98.20 Very High Very High Very High
Necrosis 24 98.16 Very High Very High Very High
Weight Gain 1 96.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 48 94.24 High High
Insulin Resistance 35 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of total Akt protein was significantly decreased in the diabetic mice aorta, but those for the p85 and p110gamma subunits of PI3-K were not.
Negative_regulation (decreased) of Gene_expression (expression) of Akt in aorta associated with diabetes mellitus
1) Confidence 0.54 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.55 Pain Relevance 0.42
The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.
Negative_regulation (decreased) of Gene_expression (expression) of Akt in aortas associated with diabetes mellitus and clonidine
2) Confidence 0.43 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.99 Pain Relevance 0.37
The mechanistic pathway involved A3AR downregulation shortly after treatment, which subsequently induced a decrease in the expression of PKAc and PKB/Akt.
Negative_regulation (decrease) of Gene_expression (expression) of PKB/Akt
3) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.03 Pain Relevance 0.35
and rabbit antiphospho-Akt1/PKB?
Negative_regulation (rabbit) of Gene_expression (/) of PKB
4) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.11 Pain Relevance 0.03
Analysis of synovia and DLN protein extracts revealed a decreased expression level of PI3K, PKB/Akt, IKK, NF-?
Negative_regulation (level) of Gene_expression (expression) of PKB/Akt in DLN
5) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526584 Disease Relevance 1.02 Pain Relevance 0.48
Further analysis of tumor cell growth regulatory proteins indicated that receptor downregulation was associated with a decrease in the level of PKB/Akt, ?
Negative_regulation (decrease) of Gene_expression (level) of PKB/Akt associated with cancer
6) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.44 Pain Relevance 0.13
The expression levels of PI3K, PKB/Akt, IKK?
Negative_regulation (levels) of Gene_expression (expression) of PKB/Akt
7) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.52 Pain Relevance 0.10
The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.
Negative_regulation (decreased) of Gene_expression (expression) of Akt in aortas associated with diabetes mellitus and clonidine
8) Confidence 0.38 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.99 Pain Relevance 0.37
and rabbit antiphospho-Akt1/PKB?
Negative_regulation (rabbit) of Gene_expression (/) of antiphospho-Akt1
9) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.11 Pain Relevance 0.03
To investigate the morphological factors relating to behavioral changes and the decrease in the phoshorylation levels of Akt and GSK3?
Negative_regulation (decrease) of Gene_expression (levels) of Akt
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.65 Pain Relevance 0.05
These decreases in levels of phosphorylated Akt and GSK3?
Negative_regulation (decreases) of Gene_expression (levels) of Akt
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.93 Pain Relevance 0.08
However, the phosphorylation levels of Akt (Ser473) and GSK3?
Negative_regulation (However) of Gene_expression (levels) of Akt
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.74 Pain Relevance 0.09
KO mice, we assessed the phosophorylation levels of Akt and GSK3?
Negative_regulation (assessed) of Gene_expression (levels) of Akt associated with targeted disruption
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.28 Pain Relevance 0.20
Regarding gene expression, Al-Regaiey and colleagues (2005) reported an increase of nearly 50% in hepatic mRNA expression of SOD2 in GHR-KO mice presumably mediated via increased FOXO protein and decreased Akt expression.
Negative_regulation (decreased) of Gene_expression (expression) of Akt
14) Confidence 0.35 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.46 Pain Relevance 0
The level of Akt in the cultures treated with 50 ?
Negative_regulation (treated) of Gene_expression (level) of Akt
15) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.30 Pain Relevance 0.04
Significantly, insulin-stimulated PKB/Akt activation was not decreased in Irs2-/- kidney at 5-6 wk (Fig. 6), and no changes in basal PKB/Akt/GSK3?
Neg (not) Negative_regulation (decreased) of Gene_expression (activation) of PKB/Akt in kidney
16) Confidence 0.29 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.16 Pain Relevance 0
Significantly, insulin-stimulated PKB/Akt activation was not decreased in Irs2-/- kidney at 5-6 wk (Fig. 6), and no changes in basal PKB/Akt/GSK3?
Neg (not) Negative_regulation (decreased) of Gene_expression (activation) of PKB/Akt in kidney
17) Confidence 0.29 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.22 Pain Relevance 0
Upon inhibition of these early processes (e.g., Akt or nNOS), the subsequent steps responsible for NMDAR sustained potentiation and MOR tolerance do not occur.
Negative_regulation (inhibition) of Gene_expression (e.g.) of Akt associated with tolerance and opioid receptor
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.05 Pain Relevance 1.07
0.25 ┬ÁM, decreased expression levels of Hsp90 client onco-proteins including HER2/neu, Akt and RAF1, compared to DMSO-treated controls.
Negative_regulation (decreased) of Gene_expression (expression) of Akt
19) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.16 Pain Relevance 0
The effect of EPO on VEGF content and expression levels of angiogenic factors and PKB in the fat grafts
Negative_regulation (levels) of Gene_expression (expression) of PKB in fat
20) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.35 Pain Relevance 0.13

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