INT122570

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 173
Total Number 175
Disease Relevance 91.44
Pain Relevance 25.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
skin 4
lung 4
aortas 3
neutrophil 3
ZR-75-1 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 505 100.00 Very High Very High Very High
Clonidine 23 100.00 Very High Very High Very High
Cannabinoid 171 99.84 Very High Very High Very High
Potency 32 99.58 Very High Very High Very High
antagonist 182 99.30 Very High Very High Very High
ischemia 101 99.22 Very High Very High Very High
opioid receptor 425 99.16 Very High Very High Very High
Inflammation 1275 99.14 Very High Very High Very High
withdrawal 106 99.08 Very High Very High Very High
Pain 59 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2169 100.00 Very High Very High Very High
Apoptosis 1603 100.00 Very High Very High Very High
Repression 5 100.00 Very High Very High Very High
Metabolic Syndrome 62 99.92 Very High Very High Very High
Diabetes Mellitus 235 99.84 Very High Very High Very High
Hypoxia 70 99.80 Very High Very High Very High
Toxicity 225 99.64 Very High Very High Very High
Autoimmune Disease 83 99.64 Very High Very High Very High
Congenital Anomalies 99 99.60 Very High Very High Very High
Skin Cancer 60 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After preincubation with an Akt inhibitor, these relaxations were not significantly different among the three Akt inhibitor-treated groups (controls, diabetics, and simvastatin-treated diabetics).
Negative_regulation (inhibitor) of Akt associated with diabetes mellitus
1) Confidence 0.59 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.94 Pain Relevance 0.31
The expression levels of both total Akt protein and clonidine-induced Ser-473-phosphorylated Akt were significantly decreased in diabetic aortas, while chronic simvastatin administration improved these decreased levels.
Negative_regulation (decreased) of Akt in aortas associated with diabetes mellitus and clonidine
2) Confidence 0.59 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18391484 Disease Relevance 0.98 Pain Relevance 0.37
Importantly, pharmacological inhibition of Akt abolished the protective effect of dexamethasone against bupivacaine-induced cell injury.
Negative_regulation (inhibition) of Akt associated with injury and dexamethasone
3) Confidence 0.58 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.69 Pain Relevance 0.56
More significantly, pharmacological inhibition of Akt abolished the LA-induced protection from bupivacaine-caused cell injury.
Negative_regulation (inhibition) of Akt
4) Confidence 0.57 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.12 Pain Relevance 0
Interestingly, downregulation of phosphorylated PKB/Akt levels by wartmannin resulted in apoptosis of synoviocytes and macrophages in rheumatoid arthritis [33].
Negative_regulation (downregulation) of PKB/Akt in macrophages associated with rheumatoid arthritis and apoptosis
5) Confidence 0.57 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.26 Pain Relevance 0.34
The expression level of total Akt protein was significantly decreased in the diabetic mice aorta, but those for the p85 and p110gamma subunits of PI3-K were not.
Negative_regulation (decreased) of Akt in aorta associated with diabetes mellitus
6) Confidence 0.54 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.55 Pain Relevance 0.41
The phosphorylation level of Akt (Thr308) was also decreased in the cortex of DGK?
Negative_regulation (decreased) of Akt in cortex
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.66 Pain Relevance 0.08
KO mice are partly caused by the reduced phosphorylation levels of Akt and GSK3?.
Negative_regulation (reduced) of Akt associated with targeted disruption
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.37 Pain Relevance 0.03
The phosphorylation level of Akt (Thr308) was also decreased in the cortex of DGK?
Negative_regulation (decreased) of Akt in cortex
9) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.96 Pain Relevance 0.08
During intervals of diminished NO production due to the loss of Akt activity and the action of CaMKII on nNOS, the zinc ions required for PKC?
Negative_regulation (loss) of Akt associated with kinase c
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.64
Naltrindole, however, has recently been described as a cell permeable inhibitor of the Akt signaling pathway [54].
Negative_regulation (inhibitor) of Akt
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.06 Pain Relevance 1.41
In a separate experiment, we examined the effect of Akt inhibition by triciribine on cell viability following dexamethasone treatment.
Spec (examined) Negative_regulation (inhibition) of Akt associated with dexamethasone
12) Confidence 0.43 Published 2010 Journal Neuroscience Section Abstract Doc Link 20038443 Disease Relevance 0.63 Pain Relevance 0.66
Peng et al. (2003) reported that dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis occurred in mice lacking Akt1 and Akt2.
Negative_regulation (lacking) of Akt1 in skin associated with dwarfism and muscular atrophy
13) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.27 Pain Relevance 0
Two weeks after axotomy, the number of p-Akt-positive NPs was only slightly reduced, but p-Akt immunofluorescence intensity was strongly increased.
Negative_regulation (reduced) of Akt
14) Confidence 0.43 Published 2009 Journal Neurosignals Section Abstract Doc Link 19346757 Disease Relevance 0.68 Pain Relevance 0.56
In a separate experiment, we determined the effect of Akt inhibition on cell viability in the presence of LA and bupivacaine.
Negative_regulation (inhibition) of Akt
15) Confidence 0.42 Published 2010 Journal Neurotoxicology Section Body Doc Link 19879292 Disease Relevance 0.16 Pain Relevance 0
To the best of our knowledge, the present study is the first to show an in-vivo link between activation of the A3AR, inhibition of PKB/Akt and downstream signaling pathways leading to apoptosis in AIA.
Negative_regulation (inhibition) of PKB/Akt associated with apoptosis and arthritis
16) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.19 Pain Relevance 0.33
The PKB/Akt kinase activity was downregulated in the IB-MECA-treated group in comparison with the vehicle-treated IB-MECA + MRS 1220 group (Figure 4c).
Negative_regulation (downregulated) of PKB/Akt
17) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.40 Pain Relevance 0.22
Further analysis of tumor cell growth regulatory proteins indicated that receptor downregulation was associated with a decrease in the level of PKB/Akt, ?
Negative_regulation (decrease) of PKB/Akt associated with cancer
18) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.44 Pain Relevance 0.13
The expression levels of PI3K, PKB/Akt, IKK?
Negative_regulation (levels) of PKB/Akt
19) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.52 Pain Relevance 0.10
Similarly, our findings demonstrating PKB/Akt inhibition followed by an increase in caspase-3 level in the IB-MECA-treated animals supports the role of PKB/Akt in ameliorating the inflammatory process.
Negative_regulation (inhibition) of PKB/Akt associated with inflammation
20) Confidence 0.41 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 1.28 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox