INT122572

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 25.23
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
cardiomyocytes 1
endothelial cells 1
brains 1
gonad 1
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 8 88.24 High High
cytokine 24 86.12 High High
Inflammation 63 85.72 High High
agonist 48 73.44 Quite High
tolerance 7 72.32 Quite High
imagery 228 61.60 Quite High
Inflammatory response 6 54.28 Quite High
Kinase C 3 48.72 Quite Low
alcohol 9 42.88 Quite Low
Hippocampus 120 40.48 Quite Low
Disease Link Frequency Relevance Heat
Obesity 3056 99.82 Very High Very High Very High
Stress 502 99.80 Very High Very High Very High
Aging 2281 99.44 Very High Very High Very High
Targeted Disruption 82 99.44 Very High Very High Very High
Hypoxia 61 99.28 Very High Very High Very High
Disease 914 97.56 Very High Very High Very High
Insulin Resistance 102 95.32 Very High Very High Very High
Increased Venous Pressure Under Development 69 95.12 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 94.88 High High
Myocardial Infarction 41 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the amount of eNOS protein in the sample could potentially contribute to the amount of phosphorylation at serine 1177, we normalized phospho-eNOS-Ser1177 levels to the amount of total eNOS protein.
Phosphorylation (phosphorylation) of eNOS
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.22 Pain Relevance 0
The phosphatidylinositol 3-kinase (PI3-K) pathway, which activates serine/threonine protein kinase Akt, enhances endothelial nitric oxide synthase (eNOS) phosphorylation and nitric oxide (NO) production.
Phosphorylation (phosphorylation) of eNOS
2) Confidence 0.61 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.45 Pain Relevance 0.21
The phosphatidylinositol 3-kinase (PI3-K) pathway, which activates serine/threonine protein kinase Akt, enhances endothelial nitric oxide synthase (eNOS) phosphorylation and nitric oxide (NO) production.
Phosphorylation (phosphorylation) of endothelial nitric oxide synthase
3) Confidence 0.61 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.45 Pain Relevance 0.21
We also demonstrated that Tg2576 mice exhibit an increased phosphorylation of eNOS at serine 1177. eNOS expression has been shown to be decreased in the brains of AD patients [44].
Phosphorylation (phosphorylation) of eNOS in brains associated with disease
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.40 Pain Relevance 0
The reduction of mitochondrial superoxide also resulted in a concomitant reduction of phosphorylation of eNOS at serine 1177, as well as phosphorylation of tau at serine 262.
Phosphorylation (phosphorylation) of eNOS
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.15 Pain Relevance 0
This effect is mediated primarily by Akt-dependent phosphorylation of eNOS at serine 1177 [30], [31].
Phosphorylation (phosphorylation) of eNOS
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 1.51 Pain Relevance 0
The reduction of mitochondrial superoxide also resulted in a concomitant reduction of phosphorylation of eNOS at serine 1177, as well as phosphorylation of tau at serine 262.
Phosphorylation (phosphorylation) of eNOS
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.15 Pain Relevance 0
In support of this possibility, SOD-2 overexpression returns the eNOS phosphorylation status back to normal. eNOS phosphorylation at serine 1177 is mediated by Akt [31], which has been extensively shown to be modulated by oxidative stress.
Phosphorylation (phosphorylation) of eNOS associated with stress
8) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.43 Pain Relevance 0
Our data support previous reports and also specifically implicate mitochondrial superoxide in Akt-dependent eNOS phosphorylation at serine 1177.
Phosphorylation (phosphorylation) of eNOS
9) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.52 Pain Relevance 0
1000 anti-phospho-eNOS-1177 (Cell Signaling Technology, Inc.
Phosphorylation (phospho) of eNOS
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.05 Pain Relevance 0
Most importantly, eNOS phosphorylation at serine 1177 has been shown to promote increased superoxide production from the enzyme [28], thereby contributing to the existing oxidative stress in these animals.
Phosphorylation (phosphorylation) of eNOS associated with stress
11) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.33 Pain Relevance 0
In support of this possibility, SOD-2 overexpression returns the eNOS phosphorylation status back to normal. eNOS phosphorylation at serine 1177 is mediated by Akt [31], which has been extensively shown to be modulated by oxidative stress.
Phosphorylation (phosphorylation) of eNOS associated with stress
12) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.43 Pain Relevance 0
Its activity, however, has not yet been measured. eNOS activity is regulated mainly via phosphorylation, with two most prominent regulatory sites: threonine 495, which is inhibitory [45] and serine 1177, which is permissive [46].
Phosphorylation (phosphorylation) of eNOS
13) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.39 Pain Relevance 0
Our data indicated that the levels of phospho-eNOS in cortical fractions were significantly increased in the Tg2576 mice (overall p?
Phosphorylation (phospho) of eNOS
14) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866668 Disease Relevance 0.20 Pain Relevance 0.06
Aging and
                       obesity reduced phosphorylation of Akt, eNOS and p38 while promoting pJNK
                       and pI?
Phosphorylation (phosphorylation) of eNOS associated with aging and obesity
15) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.96 Pain Relevance 0
There was no interaction between obesity and age on the phosphorylation of Akt
                   and eNOS. 
Phosphorylation (phosphorylation) of eNOS associated with obesity
16) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.96 Pain Relevance 0
Short-term leptin treatment at physiological level (1.0 nM) reconciled
                   the reduced phosphorylation of Akt and eNOS in young ob/ob, but
                   not the aging mice. 
Phosphorylation (phosphorylation) of eNOS associated with aging
17) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.79 Pain Relevance 0
Moreover, male androgen receptor knockout mice show decreased aortic eNOS expression and phosphorylated eNOS compared to wild type mice [28].
Phosphorylation (phosphorylated) of eNOS associated with targeted disruption
18) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.28 Pain Relevance 0
Moreover, male androgen receptor knockout mice show decreased aortic eNOS expression and phosphorylated eNOS compared to wild type mice [28].
Phosphorylation (phosphorylated) of eNOS associated with targeted disruption
19) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.28 Pain Relevance 0
It should be noted that eNOS phosphorylation at serine 1177 in castrated animals was elevated compared to gonad intact animals (Figure 8B).
Phosphorylation (phosphorylation) of eNOS in gonad
20) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.06 Pain Relevance 0

General Comments

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