INT122574

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.01
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pik3cd) signal transduction (Pik3cd) kinase activity (Pik3cd)
Pik3cd (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 12 99.66 Very High Very High Very High
tolerance 6 72.32 Quite High
Inflammatory response 22 61.36 Quite High
Inflammation 8 50.08 Quite High
cytokine 6 42.88 Quite Low
fibrosis 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 20 95.72 Very High Very High Very High
Impaired Glucose Tolerance 6 72.96 Quite High
Congenital Anomalies 3 71.24 Quite High
Obesity 54 65.04 Quite High
Apoptosis 68 64.32 Quite High
INFLAMMATION 30 61.36 Quite High
Injury 4 39.52 Quite Low
Fibrosis 8 5.00 Very Low Very Low Very Low
Cyst 8 5.00 Very Low Very Low Very Low
Hemorrhage 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphatidylinositol 3-kinase (PI3-K) pathway, which activates serine/threonine protein kinase Akt, enhances endothelial nitric oxide synthase (eNOS) phosphorylation and nitric oxide (NO) production.
Phosphorylation (phosphorylation) of PI3-K
1) Confidence 0.58 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.45 Pain Relevance 0.21
The clonidine-induced Ser-473 phosphorylation of Akt through PI3-K was significantly decreased in our model; however, that induced by ACh was not.
Phosphorylation (phosphorylation) of PI3-K associated with clonidine
2) Confidence 0.45 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.51 Pain Relevance 0.39
The clonidine-induced Ser-473 phosphorylation of Akt through PI3-K was significantly decreased in our model; however, that induced by ACh was not.
Phosphorylation (phosphorylation) of PI3-K associated with clonidine
3) Confidence 0.45 Published 2004 Journal Hypertension Section Abstract Doc Link 15505117 Disease Relevance 0.51 Pain Relevance 0.39
Nevertheless, EPO has no effect on the proliferation of HUVECs that were exposed to wortmannin which inhibits the phosphorylation of phosphatidylinositol 3-kinases (PI 3-K) and subsequently the phosphorylation of PKB, confirming that EPO stimulates the secretion of multiple growth factors, at least partially, through the PI 3-K/PKB cellular pathway.
Phosphorylation (phosphorylation) of PI 3-K
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.23 Pain Relevance 0.06
Nevertheless, EPO has no effect on the proliferation of HUVECs that were exposed to wortmannin which inhibits the phosphorylation of phosphatidylinositol 3-kinases (PI 3-K) and subsequently the phosphorylation of PKB, confirming that EPO stimulates the secretion of multiple growth factors, at least partially, through the PI 3-K/PKB cellular pathway.
Phosphorylation (phosphorylation) of PI 3-K
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.08

General Comments

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