INT122584

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 56
Total Number 60
Disease Relevance 37.61
Pain Relevance 9.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
chondrocytes 4
liver 2
colon 2
hinge 2
neurons 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 669 100.00 Very High Very High Very High
agonist 513 100.00 Very High Very High Very High
Endocannabinoid 45 100.00 Very High Very High Very High
COX-2 inhibitor 23 100.00 Very High Very High Very High
dexamethasone 12 100.00 Very High Very High Very High
Osteoarthritis 910 99.90 Very High Very High Very High
antagonist 62 99.84 Very High Very High Very High
cINOD 80 99.10 Very High Very High Very High
Arthritis 35 98.00 Very High Very High Very High
Glutamate 1 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 828 100.00 Very High Very High Very High
Obesity 419 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 143 100.00 Very High Very High Very High
Nasal Polyps 94 99.98 Very High Very High Very High
Lung Cancer 32 99.96 Very High Very High Very High
Osteoarthritis 924 99.90 Very High Very High Very High
Eczema 3 99.88 Very High Very High Very High
Diabetes Mellitus 235 99.74 Very High Very High Very High
Colon Cancer 148 99.64 Very High Very High Very High
Polyps 78 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that in inflammatory skin disorders, including hyperproliferative psoriatic epidermis and the skin of patients with atopic dermatitis, the expression of both PPARalpha and PPARgamma is decreased.
Negative_regulation (decreased) of Gene_expression (expression) of PPARalpha in skin associated with psoriasis, inflammation and eczema
1) Confidence 0.58 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.07 Pain Relevance 0.26
Four weeks of treatment resulted in a reduction in the expression of PPAR?
Negative_regulation (reduction) of Gene_expression (expression) of PPAR
2) Confidence 0.51 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.35 Pain Relevance 0.03
In

human lung cancer, decreased expression of PPAR?

Negative_regulation (decreased) of Gene_expression (expression) of PPAR in lung associated with lung cancer
3) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 2.11 Pain Relevance 0
In addition to suppressing VLDL production, PPAR?
Negative_regulation (suppressing) of Gene_expression (production) of PPAR
4) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.28 Pain Relevance 0.17
It reveals impaired gene expression for marker genes of adipogenesis, including the master regulator PPAR?
Negative_regulation (impaired) of Gene_expression (expression) of PPAR
5) Confidence 0.42 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2533346 Disease Relevance 1.23 Pain Relevance 0.05
One of the major challenges lying ahead is to gain better understanding of the molecular mechanism underlying downregulation of gene expression by PPAR?
Negative_regulation (downregulation) of Gene_expression (expression) of PPAR
6) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.15 Pain Relevance 0.10
Three PPAR isotypes, namely, PPAR?
Negative_regulation (Three) of Gene_expression (isotypes) of PPAR
7) Confidence 0.38 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.68 Pain Relevance 0.10
Albeit the lower expression of PPAR?
Negative_regulation (lower) of Gene_expression (expression) of PPAR
8) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.16 Pain Relevance 0.33
Using immunohistochemistry the protein expression of PPAR?
Negative_regulation (Using) of Gene_expression (expression) of PPAR
9) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.46 Pain Relevance 0.04
Nasal polyposis represents a chronic type of inflammation and the lower levels of PPAR?
Negative_regulation (represents) of Gene_expression (levels) of PPAR in Nasal associated with inflammation and nasal polyps
10) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.15 Pain Relevance 0.31
activation decreases hepatic aminotransferase expression in mice, PPAR?
Negative_regulation (decreases) of Gene_expression (expression) of PPAR
11) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.20 Pain Relevance 0.16
Different levels of expression of PPAR?
Negative_regulation (levels) of Gene_expression (expression) of PPAR
12) Confidence 0.36 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.30 Pain Relevance 0
Reported causal mechanisms for PPAR?
Negative_regulation (Reported) of Gene_expression (mechanisms) of PPAR
13) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.32 Pain Relevance 0.13
The expression pattern of PPAR?
Negative_regulation (pattern) of Gene_expression (expression) of PPAR
14) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.61 Pain Relevance 0
Low level of PPAR?
Negative_regulation (Low) of Gene_expression (level) of PPAR
15) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.27 Pain Relevance 0
Analysis of 42 genes associated with diabetes by RT q-PCR showed that in the liver, expression of Gk, Glut-2, apolipoprotein A-IV (ApoA-IV), PPAR?
Negative_regulation (showed) of Gene_expression (expression) of PPAR in liver associated with diabetes mellitus and disorder of lipid metabolism
16) Confidence 0.35 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.74 Pain Relevance 0.14
heterodimer revealed that the hinge region of PPAR?
Negative_regulation (revealed) of Gene_expression (region) of PPAR in hinge
17) Confidence 0.34 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Three PPAR isotypes, namely, PPAR?
Negative_regulation (Three) of Gene_expression (isotypes) of PPAR
18) Confidence 0.33 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.69 Pain Relevance 0.10
Less in known concerning PPAR?
Negative_regulation (Less) of Gene_expression (known) of PPAR
19) Confidence 0.31 Published 2003 Journal Comp Hepatol Section Abstract Doc Link PMC151270 Disease Relevance 0.66 Pain Relevance 0.03
On the other hand, two independent studies performed in mice bearing a mutation in the adenomatous polyposis coli tumor suppressor gene (APCmin) showed an increase in tumors or polyps in the colon after these mice were fed a diet containing a PPAR?
Negative_regulation (diet) of Gene_expression (containing) of PPAR in colon associated with cancer, familial adenomatous polyposis and polyps
20) Confidence 0.31 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.01 Pain Relevance 0.12

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