INT122597

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.56
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
sensory nerves 1
Lungs 1
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 6 100.00 Very High Very High Very High
ischemia 28 98.96 Very High Very High Very High
cytokine 3 98.26 Very High Very High Very High
qutenza 6 93.24 High High
anesthesia 7 90.88 High High
Inflammation 10 79.68 Quite High
alcohol 3 75.00 Quite High
isoflurane 7 74.04 Quite High
nMDA receptor 9 50.00 Quite Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 156 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Cv Unclassified Under Development 27 98.96 Very High Very High Very High
Hemorrhagic Shock 4 91.64 High High
Retinal Diseases 3 86.84 High High
Ocular Toxicity (including Many Sub-types) 2 86.56 High High
INFLAMMATION 10 79.68 Quite High
Increased Venous Pressure Under Development 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mRNA level of the hypoxia-inducible factor (HIF-1alpha) was higher at the trough than at the peak, its protein concentration in the nuclear fraction was not increased at the troughs compared with the peaks.
Transcription (level) of HIF-1alpha associated with hypoxia
1) Confidence 0.69 Published 2004 Journal Exp. Mol. Pathol. Section Abstract Doc Link 15507234 Disease Relevance 0.78 Pain Relevance 0.22
The ghrelin-enhanced acceleration of healing of ischemia/perfusion induced lesions was accompanied by enhanced expression of mRNA for HIF-1alpha and by diminution of the ischemia/reperfusion induced increase in mRNA expression for TNF-alpha.
Transcription (expression) of HIF-1alpha associated with ischemia
2) Confidence 0.46 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.90 Pain Relevance 0.53
Another important molecule, the transcription factor hypoxia inducible factor-1 (HIF-1), is well established as a key molecular signal linking oxygen level to gene expression in many tissues.
Transcription (transcription) of HIF-1 associated with hypoxia
3) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.54 Pain Relevance 0
The aim of the present study was (1) to investigate the effect of acylated ghrelin on the formation and healing of acute gastric mucosal lesions induced by ischemia-reperfusion and gastric mucosal blood flow in rats; (2) to analyse the effects of the deactivation of afferent sensory nerves with capsaicin and of the inhibition of nitric oxide (NO)-synthase by NG-nitro-l-arginine (l-NNA) on the ghrelin-induced protection; (3) to examine the influence of ghrelin on nuclear factor-kappa B (NF-kappaB) activation and on release of proinflammatory cytokines, such as tumor necrosis factor-alpha, (4) to assess the effect of ghrelin on the mRNA expression of constitutive nitric oxide synthase (cNOS), calcitonin gene related peptide (CGRP) and angiogenesis related proteins such as hypoxia inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and (5) to determine the effect of ischemia/reperfusion on the gastric mucosa expression of ghrelin in rats without and with administration of exogenous hormone.
Transcription (expression) of HIF-1alpha in sensory nerves associated with calcitonin gene related peptide, necrosis, qutenza, hypoxia, cancer, ischemia and cytokine
4) Confidence 0.35 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.97 Pain Relevance 0.51
Lungs were excised 2 or 24 h after resuscitation, and mRNA levels of tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), nitric oxide synthase 2 (iNOS), nitric oxide synthase 3, hypoxia-inducible factor 1 alpha, and heme oxygenase 1 (HO-1) were measured.
Transcription (levels) of hypoxia-inducible factor 1 alpha in Lungs associated with necrosis, hypoxia, cancer and adhesions
5) Confidence 0.15 Published 2009 Journal ASAIO J. Section Abstract Doc Link 19625952 Disease Relevance 1.36 Pain Relevance 0.37

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