INT122619

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-2) nucleus (Nkx2-2) DNA binding (Nkx2-2)
transcription factor binding (Nkx2-2)
Anatomy Link Frequency
ventral 2
neurons 1
Nkx2-2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 3 99.16 Very High Very High Very High
Raphe 16 93.04 High High
Dynorphin 1 84.96 Quite High
Pain 3 66.36 Quite High
Serotonin 3 63.12 Quite High
Neurotransmitter 2 62.72 Quite High
Action potential 11 50.00 Quite Low
imagery 21 48.88 Quite Low
Enkephalin 2 25.00 Low Low
anesthesia 3 21.36 Low Low
Disease Link Frequency Relevance Heat
Mental Disorders 3 83.04 Quite High
Pain 3 66.36 Quite High
Severe Combined Immunodeficiency 4 40.00 Quite Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Teratoma 10 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 7 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that exposure of mouse ES cells to extremely low frequency magnetic fields triggered the expression of GATA-4 and Nkx-2.5, acting as cardiac lineage-promoting genes in different animal species, including humans.
Gene_expression (expression) of Nkx-2
1) Confidence 0.36 Published 2005 Journal FASEB J. Section Abstract Doc Link 15507470 Disease Relevance 0 Pain Relevance 0.04
Although Nkx2.2 is expressed in the progenitors of all 5-HTergic neurons in hindbrain, evidence from null mutant mice show that it is only required for the generation of 5-HTergic neurons in the dorsal raphe nucleus, one cluster neurons in pons group [9], and GATA3 is thought to be required for the differentiation of the medulla oblongata group [10].
Gene_expression (expressed) of Nkx2 in neurons associated with medulla and raphe
2) Confidence 0.10 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.15 Pain Relevance 0.27
Compared to controls, dorsomorphin treatment increased expression of the early cardiac marker Nkx2.5 by 11.4-fold (Figure 1C), the cardiac myosin heavy chain gene (Myh6) by 125-fold (Figure 1D), and the cardiac myosin light chain 2 (Myl2) by 34.2-fold (Figure S1F) at day 10 of differentiation.
Gene_expression (expression) of Nkx2
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0 Pain Relevance 0
Reverse transcription polymerase chain reaction (RT-PCR) was used to compare the expression of embryonic markers (Oct4, NANOG, Rex1), cardiac transcription factors (Nkx2.5, MEF2C), ventricular specific proteins (?
Gene_expression (expression) of Nkx2
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Nkx2 in ventral
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Nkx2 in ventral
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

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