INT122643

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 96.32 Very High Very High Very High
antagonist 2 94.44 High High
qutenza 3 80.68 Quite High
spastic colon 1 64.24 Quite High
Serotonin 1 53.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 73.96 Quite High
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream signaling required G-protein activation and phosphorylation as intracellularly administered GDP-beta-S [guanosine 5'-O-(2-thiodiphosphate], protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly blocked serotonergic facilitation of TRPV1 function; 5-HT2 receptor-mediated facilitation was also inhibited by a PKC inhibitor.
Phosphorylation (phosphorylation) of G-protein
1) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509739 Disease Relevance 0.07 Pain Relevance 0.39

General Comments

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