INT122647

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.63
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a)
protein complex (Tnfrsf1a)
Anatomy Link Frequency
dorsal root ganglion 1
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 60 99.84 Very High Very High Very High
cytokine 11 95.68 Very High Very High Very High
antagonist 3 94.96 High High
Inflammatory response 10 78.40 Quite High
Inflammation 75 77.32 Quite High
Calcitonin gene-related peptide 2 60.08 Quite High
substance P 2 57.44 Quite High
Hyperalgesia 24 50.00 Quite Low
IPN 2 38.64 Quite Low
Pain 17 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 60 99.36 Very High Very High Very High
Communicable Diseases 19 92.20 High High
Nociception 14 92.00 High High
Necrosis 16 88.88 High High
Cancer 16 88.52 High High
Urinary Tract Infection 1 86.88 High High
INFLAMMATION 81 78.04 Quite High
Acute-phase Reaction 9 74.72 Quite High
Sepsis 2 73.68 Quite High
Endotoxemia 1 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, TNFR1, TNFR2, L19 and StAR mRNA expression were quantitated through kinetic reverse transcription (RT) – polymerase chain reaction (PCR) using the Bio Rad iCycler (Bio Rad Laboratories, Hercules, CA, USA).
Transcription (expression) of TNFR1
1) Confidence 0.60 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0 Pain Relevance 0
The TNFR mRNA level was expressed as a ratio to 18S RNA.
Transcription (expressed) of TNFR
2) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.11 Pain Relevance 0.05
Using RT-PCR and Northern blotting TNFR1 and TNFR2 mRNAs were found to be constitutively expressed and increased after LPS.
Transcription (expressed) of TNFR1
3) Confidence 0.52 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 1.01 Pain Relevance 0.39
Therefore, we differentiated the neuronal and non-neuronal sites of TNFalpha, TNFR1, and TNFR2 mRNA synthesis in dorsal root ganglion (DRG) of control rats and evaluated how their expression is altered under systemic challenge with LPS.
Transcription (synthesis) of TNFR1 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.52 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.84 Pain Relevance 0.26
Similarly the abundance of TNFRSF1A transcript was increased.
Transcription (abundance) of TNFRSF1A
5) Confidence 0.09 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.66 Pain Relevance 0.33

General Comments

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