INT12265

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Context Info
Confidence 0.63
First Reported 1982
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 168
Total Number 169
Disease Relevance 104.89
Pain Relevance 19.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 6
cerebrospinal fluid 4
lung 4
CII 3
OGBs 3
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 909 100.00 Very High Very High Very High
cytokine 647 100.00 Very High Very High Very High
Pain 102 100.00 Very High Very High Very High
Nicotine 94 100.00 Very High Very High Very High
rheumatoid arthritis 284 99.84 Very High Very High Very High
Arthritis 325 99.82 Very High Very High Very High
Multiple sclerosis 225 99.64 Very High Very High Very High
Central nervous system 215 99.60 Very High Very High Very High
diclofenac 84 99.60 Very High Very High Very High
spinal inflammation 21 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 969 100.00 Very High Very High Very High
Influenza Virus Infection 604 100.00 Very High Very High Very High
Neuromyelitis Optica 283 100.00 Very High Very High Very High
Chlamydia Infection 153 100.00 Very High Very High Very High
Togavirus Infection 73 100.00 Very High Very High Very High
Hepatitis A Virus Infection 15 100.00 Very High Very High Very High
Cancer 661 99.98 Very High Very High Very High
Bullous Skin Disease 305 99.98 Very High Very High Very High
Age-related Macular Degeneration 16 99.90 Very High Very High Very High
Hypergammaglobulinemia 12 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ether extract also had significant immunological facilitation effect in mice, it could increase the thymus gland weight and the serum IgG content.
Positive_regulation (increase) of IgG in gland
1) Confidence 0.63 Published 1998 Journal Zhong Yao Cai Section Abstract Doc Link 12567527 Disease Relevance 0 Pain Relevance 0.10
All patients had significant elevations of serum IgG on the day after completion of treatment.
Positive_regulation (elevations) of IgG
2) Confidence 0.59 Published 1984 Journal Blood Section Abstract Doc Link 6592011 Disease Relevance 0.26 Pain Relevance 0.10
During the primary antibody response in mice, an elevation of IgG antibody levels was only observed on day 28.
Positive_regulation (elevation) of IgG
3) Confidence 0.58 Published 2007 Journal Toxicon Section Abstract Doc Link 17391720 Disease Relevance 0.36 Pain Relevance 0.09
After boosting, high antibody levels were detected between days 49 and 70, with a 12-fold increase in IgG level over control values at day 49.
Positive_regulation (increase) of IgG
4) Confidence 0.58 Published 2007 Journal Toxicon Section Abstract Doc Link 17391720 Disease Relevance 0.33 Pain Relevance 0.08
Although part of the glycine-independent current remains uncharacterized, these results confirm that a virus-induced immunopathology produces IgG clones that activate ionotropic glutamate receptors and that could, thereby, contribute to the excitotoxic neurological syndrome observed in LP-BM5-infected mice.
Positive_regulation (produces) of IgG associated with syndrome and glutamate receptor
5) Confidence 0.50 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741402 Disease Relevance 0.10 Pain Relevance 0.21
These include the need for intramuscular administration, pain at the site of injection, loss of immunoglobulin G (IgG) extravascularly, limitations on the degree to which serum IgG can be increased, incomplete and delayed onset of absorption, and limitations on the volume of material administered.
Positive_regulation (increased) of IgG associated with pain
6) Confidence 0.49 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3118708 Disease Relevance 0.28 Pain Relevance 0.10
Comparison for anti-murine typhus IgG ELISA assays using 45 sera and filterpaper bloodspot pairs demonstrated agreement for 42 (93%) – two pairs were negative for IgG from filterpaper but positive from serum and one pair positive for IgG from filterpaper but negative from serum.
Positive_regulation (negative) of IgG associated with rickettsiaceae infection
7) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.53 Pain Relevance 0
Some patients may develop specific IgG without developing disease and some will lose their specific IgG during their lifetime.
Positive_regulation (lose) of IgG associated with disease
8) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.72 Pain Relevance 0
Comparison of anti-scrub typhus IgG ELISA assays using 47 sera and filterpaper bloodspot pairs demonstrated agreement (i.e. positive or negative for IgG against O. tsutsugamushi) for 45 (96%) – one pair was negative for IgG from filterpaper but positive from serum and one pair positive for IgG from filterpaper but negative from serum.
Positive_regulation (negative) of IgG associated with rickettsiaceae infection
9) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2998433 Disease Relevance 0.31 Pain Relevance 0
Among the IgGs, the two cytophilic classes, IgG1 and IgG3, were the most abundant (Figure 1) and they both increased as a function of age, whereas the increase was modest for IgG2 and IgM antibodies, and low for IgG4 antibodies in all age groups.
Positive_regulation (increased) of IgG1
10) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.22 Pain Relevance 0
Following intralesional CHC injection of 3,000–12,650 U, an increase of twofold to 10-fold in IgG levels was seen at 1–2 months postinjection in 88% of patients.
Positive_regulation (increase) of IgG
11) Confidence 0.45 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.34 Pain Relevance 0
IgG level augmented consistently against NDL and RL while IgA response was detected only to NDL.
Positive_regulation (augmented) of IgG
12) Confidence 0.45 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17141437 Disease Relevance 0.56 Pain Relevance 0.08
Based on these results one could consider increasing maternal antigen-specific IgG levels (e.g. maternal immunization) as a possible method for the prevention of allergic disease in progeny.
Positive_regulation (increasing) of IgG associated with hypersensitivity, immunization and disease
13) Confidence 0.45 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.14 Pain Relevance 0
During this treatment serum levels of murine IgG increased to 43.4 micrograms/ml.
Positive_regulation (increased) of IgG
14) Confidence 0.42 Published 1988 Journal Int. J. Cancer Suppl. Section Abstract Doc Link 3162451 Disease Relevance 0.48 Pain Relevance 0.08
Antibody titers against Bartonella (B.) henselae were 1:32 for IgM 3 weeks after the onset of the symptoms and 1:64 for IgG 8 weeks after the onset.
Positive_regulation (1:64) of IgG
15) Confidence 0.42 Published 2000 Journal J. Vet. Med. Sci. Section Abstract Doc Link 11193351 Disease Relevance 0.64 Pain Relevance 0.16
Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (induces) of IgG in T cells associated with diclofenac
16) Confidence 0.39 Published 2002 Journal Toxicol. Lett. Section Title Doc Link 11992736 Disease Relevance 0.55 Pain Relevance 0.56
Streptozotocin (1.00 mg) caused significant increases in PLN cellularity, IgM AFCs, and selectively induced IgG(2a) and IgG(2b) AFCs against TNP-OVA.
Positive_regulation (increases) of IgG
17) Confidence 0.39 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0.10 Pain Relevance 0.41
However, in contrast to streptozotocin, diclofenac caused a selective dose-dependent increase in both IgG(1) and IgE AFCs.
Positive_regulation (increase) of IgG associated with diclofenac
18) Confidence 0.39 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.35
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of IgG in CII associated with immunization and acupuncture
19) Confidence 0.33 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.91 Pain Relevance 0.91
Recently, IgG was detected in the perikarya of motor neurons of the lumbar spinal cord in mice 24 hours after intraperitoneal injection of IgG derived from sera of ALS patients [31].
Positive_regulation (derived) of IgG in spinal cord associated with motor neuron diseases and spinal cord
20) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.61 Pain Relevance 0.24

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