INT122657

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.14
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1A) signal transducer activity (MTNR1A)
Anatomy Link Frequency
plasma 1
MT2 1
gut 1
MTNR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 15 98.08 Very High Very High Very High
nud 48 97.74 Very High Very High Very High
5HT 10 97.68 Very High Very High Very High
depression 45 95.76 Very High Very High Very High
antidepressant 48 91.52 High High
agonist 3 75.00 Quite High
Pain 1 61.76 Quite High
Dismenorea 1 61.44 Quite High
Inflammation 6 41.44 Quite Low
fluoxetine 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 34 98.96 Very High Very High Very High
Scoliosis 37 97.96 Very High Very High Very High
Dyspepsia 48 97.74 Very High Very High Very High
Gastroesophageal Reflux Disease 294 97.40 Very High Very High Very High
Depression 47 95.76 Very High Very High Very High
Ulcers 36 93.68 High High
Peptic Ulcer 12 88.96 High High
Duodenal Ulcer 6 77.44 Quite High
Disease 43 75.00 Quite High
Recurrence 20 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Qiu et al. performed genetic association studies to investigate variation of the melatonin receptor 1A (MTNR1A) and 1B genes in girls with adolescent idiopathic scoliosis (AIS) patients compared to normal controls.
Spec (investigate) Positive_regulation (variation) of MTNR1A associated with scoliosis
1) Confidence 0.49 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2822427 Disease Relevance 0.36 Pain Relevance 0
It stimulates the activity of melatonin MT1 and MT2 receptors and inhibits the activity of serotonin 5HT-2C receptor subtypes.
Positive_regulation (stimulates) of MT1 in MT2 associated with 5ht and serotonin
2) Confidence 0.39 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2785860 Disease Relevance 0.30 Pain Relevance 0.23
Elevated serum melatonin levels during human late pregnancy and labour.
Positive_regulation (Elevated) of melatonin
3) Confidence 0.06 Published 1997 Journal J Obstet Gynaecol Section Title Doc Link 15511919 Disease Relevance 0 Pain Relevance 0.12
In addition, there is a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decreased in BAO and a significant increase in serum gastrin and melatonin levels.
Positive_regulation (increase) of melatonin
4) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.45 Pain Relevance 0.08
These protective effects were accompanied by gradual increase in plasma melatonin levels suggesting that topical melatonin exerts a local protective action on gastric mucosa, acting via circulation following its absorption form the gut.
Positive_regulation (increase) of melatonin in gut
5) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.15 Pain Relevance 0
There was also a significant increase in the tone of the LES in the form of increased LES pressure, a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decrease in BAO, and a significant increase in serum gastrin and mean melatonin levels relative to pretreated patients.
Positive_regulation (increase) of melatonin
6) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.78 Pain Relevance 0.12
Table 1 illustrates that pretreated Patients with GERD showed heartburn, epigastric pain, and significant decrease in LES pressure, residual pressure, relaxation percentage, pH, serum gastrin and mean melatonin level and a significant increase in relaxation duration and basal acid output (BAO) relative to control group.
Positive_regulation (increase) of melatonin associated with gastroesophageal reflux disease and nud
7) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.95 Pain Relevance 0.09
However, Otsuka et al. [20] reported that acute stress induced gastric lesions in rats are accompanied by increased plasma melatonin.
Positive_regulation (increased) of melatonin in plasma associated with stress
8) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.44 Pain Relevance 0
There was also a non-significant change in the tone of the LES, a non-significant change in the residual pressure, relaxation duration, relaxation percentage, a significant increase in the pH with a significant decrease in BAO, a significant increase in serum gastrin and a non - significant increase in the melatonin level.
Positive_regulation (increase) of melatonin
9) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.72 Pain Relevance 0.12

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