INT122660

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.68
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CACNA1A, DNAH8) small molecule metabolic process (CACNA1A) cilium (DNAH8)
transmembrane transport (CACNA1A) cell death (CACNA1A) nucleus (CACNA1A)
CACNA1A (Homo sapiens)
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 91 100.00 Very High Very High Very High
Calcium channel 6 94.16 High High
Multiple sclerosis 1 11.76 Low Low
headache 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Neuronal excitability 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 53 100.00 Very High Very High Very High
Migraine Disorders 55 93.68 High High
Migraine Without Aura 13 86.72 High High
Disease 2 82.40 Quite High
Epilepsy 1 74.60 Quite High
Demyelinating Disease 5 52.08 Quite High
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some families, mutations in the ATP1A2 gene encoding the alpha2 subunit of the Na+, K+-ATPase are associated with FHM, linked to 1q23.
FHM Binding (associated) of ATPase associated with migraine
1) Confidence 0.28 Published 2004 Journal Ann. Med. Section Abstract Doc Link 15513297 Disease Relevance 1.36 Pain Relevance 1.33
Further investigation of these FHM susceptibility regions has subsequently implicated a specific ATPase gene ATP1A2 on chromosome 1q23.
FHM Binding (implicated) of ATPase associated with migraine
2) Confidence 0.07 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.33 Pain Relevance 0.76

General Comments

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