INT122665

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pak1) Golgi apparatus (Pak1) plasma membrane (Pak1)
nucleus (Pak1) cytoplasm (Pak1)
Pak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 9 99.98 Very High Very High Very High
Inflammation 1 67.04 Quite High
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 6 90.88 High High
INFLAMMATION 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the activation state of the components upstream of p38 and JNK showed that NSAIDs inhibit the serine-threonine kinase p21-activated protein kinase 1 (Pak1) and the small guanosine 5'-triphosphatase (GTPase) Rac, as well as the Rac-specific guanine nucleotide exchanger, Vav.
Negative_regulation (inhibit) of Pak1 associated with cinod
1) Confidence 0.04 Published 2005 Journal Blood Section Abstract Doc Link 15514010 Disease Relevance 0.61 Pain Relevance 0.75

General Comments

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