INT122675

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 6.40
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
5-HT neuron 4
retina 2
bowel 2
synapses 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 210 100.00 Very High Very High Very High
Raphe 81 99.70 Very High Very High Very High
Dopamine 58 99.56 Very High Very High Very High
Inflammation 235 99.32 Very High Very High Very High
antagonist 13 99.32 Very High Very High Very High
fluoxetine 34 98.60 Very High Very High Very High
sSRI 29 98.38 Very High Very High Very High
Neurotransmitter 33 96.24 Very High Very High Very High
spastic colon 20 95.80 Very High Very High Very High
agonist 11 91.20 High High
Disease Link Frequency Relevance Heat
Infection 15 99.70 Very High Very High Very High
Inflammatory Bowel Disease 197 99.60 Very High Very High Very High
INFLAMMATION 227 99.32 Very High Very High Very High
Colitis 127 99.12 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

23 98.76 Very High Very High Very High
Anxiety Disorder 11 98.28 Very High Very High Very High
Functional Bowel Disorder 8 95.80 Very High Very High Very High
Constipation 3 90.56 High High
Diarrhoea 10 87.84 High High
Hyperplasia 8 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data were supported by ELISA assays, which showed enhanced 5-HT release during colitis, by immunohistochemical analyses, which showed increases in EC cell numbers, and by real-time PCR, which identified a decrease in SERT mRNA expression in the mucosa during colitis.
Negative_regulation (decrease) of Gene_expression (expression) of SERT mRNA associated with colitis
1) Confidence 0.59 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20019165 Disease Relevance 0.65 Pain Relevance 0.27
Mucosal SERT and tryptophan hydroxylase-1 expression are decreased in experimental inflammation, IBS-C, IBS-D, and ulcerative colitis.
Negative_regulation (decreased) of Gene_expression (expression) of SERT associated with inflammatory bowel disease and inflammation
2) Confidence 0.56 Published 2005 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 15798484 Disease Relevance 1.02 Pain Relevance 0.43
Serotonin-selective reuptake transporter (SERT) expression is decreased in animal models of intestinal inflammation and in individuals with inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS), and it is possible that resultant changes in intestinal serotonin signalling contribute to the manifestation of clinical features associated with these disorders.
Negative_regulation (decreased) of Gene_expression (expression) of SERT in bowel associated with inflammatory bowel disease, inflammation, spastic colon and serotonin
3) Confidence 0.51 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.39 Pain Relevance 0.42
Infection significantly reduced jejunal SERT expression, with luminance values falling from 61.0 (45.1-98.3) to a nadir of 11.6 (0-36.0) units at day 9, P<0.001.
Negative_regulation (reduced) of Gene_expression (expression) of SERT associated with infection
4) Confidence 0.48 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16336502 Disease Relevance 1.08 Pain Relevance 0.29
In mice, chronic treatment with the SSRI fluoxetine (Prozac) increases miR-16 levels in serotonergic raphe nuclei, which reduces SERT expression.
Negative_regulation (reduces) of Gene_expression (expression) of SERT associated with raphe, ssri and fluoxetine
5) Confidence 0.40 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.78
We found that the level of central 5-HT in Lmx1b iCKO mice is reduced to 60% of controls, and that the expression of 5-HT neuron-associated genes such as Tph2, Sert and Vmat2 are down-regulated in Lmx1b iCKO mice.
Negative_regulation (-) of Gene_expression (expression) of Sert in 5-HT neuron
6) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.31
We found that the level of central 5-HT in Lmx1b iCKO mice is reduced to 60% of controls, and that the expression of 5-HT neuron-associated genes such as Tph2, Sert and Vmat2 are down-regulated in Lmx1b iCKO mice.
Negative_regulation (down) of Gene_expression (expression) of Sert in 5-HT neuron
7) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.31
This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression.
Negative_regulation (deficient) of Gene_expression (expression) of 5-HTT
8) Confidence 0.38 Published 2004 Journal Science Section Abstract Doc Link 15514160 Disease Relevance 0.09 Pain Relevance 0.23
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown.
Negative_regulation (Reduced) of Gene_expression (expression) of 5-HTT associated with anxiety disorder and serotonin
9) Confidence 0.37 Published 2004 Journal Science Section Abstract Doc Link 15514160 Disease Relevance 0.10 Pain Relevance 0.21
In mice lacking EphB1, expression of Sert in the retina was maintained in a pattern indistinguishable from wild type (Figure 8B).
Negative_regulation (maintained) of Gene_expression (expression) of Sert in retina
10) Confidence 0.36 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.20 Pain Relevance 0
In situ hybridization probes against Tph2, Sert, Aadc and Dopamine ?
Negative_regulation (hybridization) of Gene_expression (probes) of Sert associated with dopamine
11) Confidence 0.34 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0.21 Pain Relevance 0.05
The short allele reduces transcriptional activity of the gene and results in decreased expression of the serotonin transporter.
Negative_regulation (decreased) of Gene_expression (expression) of serotonin transporter associated with serotonin
12) Confidence 0.27 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.17 Pain Relevance 0.09
Second, E2 inhibits the expression of the gene for the serotonin reuptake transporter (SERT) and acts as an antagonist at the SERT, thus promoting the actions of serotonin by increasing the time that it remains available in synapses and interstitial spaces [22,23].
Negative_regulation (inhibits) of Gene_expression (expression) of SERT in synapses associated with antagonist and serotonin
13) Confidence 0.12 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.15 Pain Relevance 0.69
There is evidence that SERT expression is decreased in human IBD [41] as well as in mice as a result of TNBS-induced colitis [71].
Negative_regulation (decreased) of Gene_expression (expression) of SERT associated with colitis and inflammatory bowel disease
14) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.63 Pain Relevance 0.13
A further factor that may act to increase 5-HT levels is that expression of the serotonin reuptake transporter (SERT) is reduced.
Negative_regulation (reduced) of Gene_expression (expression) of SERT associated with serotonin
15) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.38 Pain Relevance 0.21
In particular, a short variant of 5-HTTLPR appears to be associated with repressed transcriptional activity of the promoter, decreased 5-HTT expression, and decreased 5-HT uptake when compared with a long variant of 5-HTTLPR [13].
Negative_regulation (decreased) of Gene_expression (expression) of 5-HTT
16) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.79 Pain Relevance 0.27

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