INT12269

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 39
Total Number 43
Disease Relevance 6.98
Pain Relevance 18.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
neurons 6
muscle 5
SH-SY5Y 2
spinal 2
V neurons 2
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 226 100.00 Very High Very High Very High
antinociception 24 100.00 Very High Very High Very High
Serotonin 15 100.00 Very High Very High Very High
Nicotine 183 99.92 Very High Very High Very High
GABAergic 305 99.84 Very High Very High Very High
antagonist 93 99.84 Very High Very High Very High
qutenza 74 99.84 Very High Very High Very High
dorsal root ganglion 8 99.84 Very High Very High Very High
nociceptor 26 99.58 Very High Very High Very High
Spinal nerve ligature 20 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 25 99.84 Very High Very High Very High
Nociception 69 99.16 Very High Very High Very High
Injury 4 99.04 Very High Very High Very High
Toxicity 11 98.84 Very High Very High Very High
Pheochromocytoma 5 98.12 Very High Very High Very High
Neuropathic Pain 24 97.44 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.36 Very High Very High Very High
Brain Injury 15 97.00 Very High Very High Very High
Dementia 5 96.32 Very High Very High Very High
Pain 24 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evoked nAChR currents could be clustered into three broad classes: fast transient, biphasic, and slow desensitizing currents, consistent with multiple subtypes of nAChR expressed in DRG [J.R.
Gene_expression (expressed) of nAChR in DRG associated with dorsal root ganglion
1) Confidence 0.73 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694269 Disease Relevance 0.71 Pain Relevance 0.95
BACKGROUND: Neuronal nicotinic acetylcholine receptor (nAChR) agonists produce antinociception in animals. nAChRs exist almost exclusively on presynaptic terminals in the central nervous system and stimulate neurotransmitter release.
Gene_expression (produce) of nAChR in central nervous system associated with antinociception, neurotransmitter, agonist and central nervous system
2) Confidence 0.71 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12170059 Disease Relevance 0 Pain Relevance 0.37
Embryonic-type nicotinic acetylcholine receptor (nAChR) gene expression is regulated by muscle activity.
Gene_expression (expression) of nAChR in muscle
3) Confidence 0.69 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0
We have addressed this issue by using a rat primary muscle cell culture system that mimics the in vivo effects of muscle activity on nAChR expression.
Gene_expression (expression) of nAChR in muscle
4) Confidence 0.69 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.07
In addition, muscle inactivity caused either by tetrodotoxin or denervation increases cAMP levels and protein kinase A activity, consistent with their proposed role in mediating nAChR gene expression.
Gene_expression (expression) of nAChR gene in muscle associated with tetrodotoxin
5) Confidence 0.69 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.23
We report here that the suppression of nAChR gene expression by muscle activity can be reversed by increasing intracellular cAMP levels.
Gene_expression (expression) of nAChR gene in muscle
6) Confidence 0.69 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.15
To determine whether neuronal nicotine acetylcholine receptors (nAChR) are present on capsaicin-sensitive neurons, whole cell patch-clamp recordings were performed on rat trigeminal ganglion cells.
Gene_expression (present) of nAChR in neurons associated with ganglion cysts, qutenza, trigeminal ganglion and nicotine
7) Confidence 0.60 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8764165 Disease Relevance 0.36 Pain Relevance 0.80
The differences in these nAChR-mediated effects could be related to the expression of different nAChR subtypes located on nociceptive neurons.
Gene_expression (expression) of nAChR in neurons associated with nociception
8) Confidence 0.50 Published 2004 Journal Auton Neurosci Section Abstract Doc Link 15296793 Disease Relevance 0.39 Pain Relevance 0.13
Our results indicate an additional non-neuronal expression of nAChR subunits in the rat heart that, as in skeletal muscle, precedes functional innervation and then undergoes changes in its distribution on the surface of cells.
Gene_expression (expression) of nAChR in skeletal muscle
9) Confidence 0.44 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15549397 Disease Relevance 0 Pain Relevance 0.15
However, multiple nAChR subtypes exist, the most abundant of which contain alpha4 and beta2 subunits.
Gene_expression (exist) of nAChR
10) Confidence 0.37 Published 2000 Journal Brain Res. Section Abstract Doc Link 10882784 Disease Relevance 0.14 Pain Relevance 0.54
In contrast, the expression of tryptophan hydroxylase, as well as, the alpha7 nAChR subunit in antisense-infused rats was similar to that observed in saline- and missense-treated controls.
Gene_expression (expression) of nAChR
11) Confidence 0.32 Published 2000 Journal Brain Res. Section Abstract Doc Link 10882784 Disease Relevance 0.33 Pain Relevance 0.74
Muscle electrical activity suppresses expression of the embryonic-type (alpha, beta, gamma, and delta) nicotinic acetylcholine receptor (nAChR) genes.
Gene_expression (expression) of nAChR in Muscle
12) Confidence 0.29 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.05
Double immunohistochemical labeling revealed near-complete overlap of expression of the serotonin marker tryptophan hydroxylase and the alpha4 nAChR subunit in the dorsal raphe nucleus.
Gene_expression (expression) of nAChR in dorsal associated with raphe and serotonin
13) Confidence 0.29 Published 2000 Journal Brain Res. Section Abstract Doc Link 10882784 Disease Relevance 0.33 Pain Relevance 0.83
Based on concentration response curves formed by nicotinic agonists [ACh, nicotine, dimethyl phenyl piperazinium (DMPP), cytisine] evidence emerged of two distinct nAChR differentially expressed in type 4 (alpha3beta4) and types 5 and 8 (alpha3beta4 alpha5).
Gene_expression (expressed) of nAChR associated with nicotine and agonist
14) Confidence 0.28 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15483069 Disease Relevance 0.20 Pain Relevance 0.99
A series of potent neuronal nicotinic acetylcholine receptor (nAChR) ligands based on a 3,8-diazabicyclo[4.2.0]octane core have been synthesized and evaluated for affinity and agonist efficacy at the human high affinity nicotine recognition site (halpha4beta2) and in a rat model of persistent nociceptive pain (formalin model).
Gene_expression (synthesized) of nAChR in neuronal associated with eae, nicotine, agonist and painful pain
15) Confidence 0.27 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 17181167 Disease Relevance 0.09 Pain Relevance 0.35
These myotubes, when stimulated with extracellular electrodes, suppressed endogenous embryonic-type nAChR gene expression compared to those treated with TTX.
Gene_expression (expression) of nAChR gene in myotubes associated with tetrodotoxin
16) Confidence 0.25 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.28
In a double immunohistochemical labeling experiment, coexpression of the serotonin marker tryptophan hxdroxylase and the alpha4 nAChR subunit in NRM neurons was observed.
Gene_expression (coexpression) of nAChR in neurons associated with raphe magnus and serotonin
17) Confidence 0.22 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651224 Disease Relevance 0 Pain Relevance 0.72
Whereas alpha7 was co-expressed with other nAChR in type 8 cells.
Gene_expression (co-expressed) of nAChR
18) Confidence 0.19 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15483069 Disease Relevance 0.24 Pain Relevance 1.05
In contrast, all A delta nociceptors (types 4, 6, and 9) expressed slowly decaying nAChR.
Gene_expression (expressed) of nAChR in nociceptors associated with nociceptor
19) Confidence 0.19 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15483069 Disease Relevance 0.24 Pain Relevance 0.99
Evidence is provided that functional alpha7- and alpha4beta2-like nAChRs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the CA1 field of the rat hippocampus and in the human cerebral cortex and that activation of the different nAChR subtypes present in the preterminal/terminal areas of the interneurons triggers the tetrodotoxin-sensitive release of GABA.
Gene_expression (present) of nAChR in cerebral cortex associated with tetrodotoxin, gaba, hippocampus and cerebral cortex
20) Confidence 0.18 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942040 Disease Relevance 0 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox