INT12270

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.47
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
muscle 3
lymph node 1
cerebral cortex 1
brain 1
central nervous system 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
cytokine 1 100.00 Very High Very High Very High
antinociception 1 100.00 Very High Very High Very High
Hippocampus 4 98.92 Very High Very High Very High
cerebral cortex 4 98.28 Very High Very High Very High
Nicotine 28 97.84 Very High Very High Very High
tetrodotoxin 8 97.30 Very High Very High Very High
Central nervous system 1 96.76 Very High Very High Very High
Sciatic nerve 2 95.84 Very High Very High Very High
Electroencephalography 7 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Overactive Bladder 1 99.32 Very High Very High Very High
Brain Injury 28 99.20 Very High Very High Very High
Disorders Of The Lacrimal System 1 99.04 Very High Very High Very High
Cognitive Disorder 16 98.88 Very High Very High Very High
Disease 1 92.36 High High
Injury 16 88.68 High High
Immunization 2 88.08 High High
Experimental Autoimmune Neuritis 1 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings show that AChR resistance results in reduced cardiac muscarinic receptor function leading to cardiovagal insufficiency.
Gene_expression (resistance) of AChR
1) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15951345 Disease Relevance 0 Pain Relevance 0.14
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Gene_expression (expression) of AChR in lymph node associated with necrosis, cancer, tolerance and cytokine
2) Confidence 0.50 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.14 Pain Relevance 0.49
BACKGROUND: Neuronal nicotinic acetylcholine receptor (nAChR) agonists produce antinociception in animals. nAChRs exist almost exclusively on presynaptic terminals in the central nervous system and stimulate neurotransmitter release.
Gene_expression (produce) of nicotinic acetylcholine receptor in central nervous system associated with antinociception, neurotransmitter, agonist and central nervous system
3) Confidence 0.50 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12170059 Disease Relevance 0 Pain Relevance 0.37
Injection of this solution caused lacrimation and urination in the rats, which are agonistic effects of the AChR and were not due to the receptor blockage.


Gene_expression (effects) of AChR associated with disorders of the lacrimal system and overactive bladder
4) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2875724 Disease Relevance 0.39 Pain Relevance 0.24
TBI caused significant deficits in alpha7* nAChr expression in several regions of the hippocampus and cerebral cortex, which were largely unaffected by intermittent nicotine treatment.
Gene_expression (expression) of nAChr in cerebral cortex associated with nicotine, hippocampus, cerebral cortex and brain injury
5) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 1.12 Pain Relevance 0.48
Previous studies from our laboratory have shown that experimental rat brain injury causes a rapid and persistent decrease in CNS alpha7* nicotinic cholinergic receptor (nAChr) expression.
Gene_expression (expression) of nAChr in brain associated with brain injury
6) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 0.90 Pain Relevance 0.28
These results suggest that nicotine is efficacious at attenuating CCI-induced cognitive deficits in a manner independent of changes in alpha7* nAChr expression, perhaps via up-regulation of non-alpha7* nAChrs.
Gene_expression (expression) of nAChr associated with cognitive disorder and nicotine
7) Confidence 0.38 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 0.80 Pain Relevance 0.35
Embryonic-type nicotinic acetylcholine receptor (nAChR) gene expression is regulated by muscle activity.
Gene_expression (expression) of Embryonic-type nicotinic acetylcholine receptor in muscle
8) Confidence 0.35 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0
Muscle electrical activity suppresses expression of the embryonic-type (alpha, beta, gamma, and delta) nicotinic acetylcholine receptor (nAChR) genes.
Gene_expression (expression) of nicotinic acetylcholine receptor in Muscle
9) Confidence 0.33 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.05
TBI caused significant deficits in alpha7* nAChr expression in several regions of the hippocampus and cerebral cortex, which were largely unaffected by intermittent nicotine treatment.
Gene_expression (expression) of nAChr in hippocampus associated with nicotine, hippocampus, cerebral cortex and brain injury
10) Confidence 0.15 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 1.12 Pain Relevance 0.48
Embryonic chick muscle cell cultures treated with the muscle activity blocking agents decamethonium (DCM), d-tubocurare (TBC), and tetrodotoxin (TTX) or co-cultured with cholinergic neurons were examined for the influence of muscle activity on nuclear aggregation and its effects on AChR alpha-, gamma-, and delta-subunit message expression. mRNA was measured by in situ hybridization and nuclei were visualized by bis-benzimide DNA staining.
Gene_expression (expression) of AChR in muscle associated with tetrodotoxin
11) Confidence 0.09 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.19

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