INT12271

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Context Info
Confidence 0.52
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.62
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
muscle 6
filaments 2
neurons 2
myotubes 2
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 28 98.72 Very High Very High Very High
Antinociceptive 1 97.32 Very High Very High Very High
Central nervous system 1 83.52 Quite High
GABAergic 78 82.60 Quite High
Root ganglion neuron 1 75.00 Quite High
sodium channel 2 54.00 Quite High
qutenza 1 35.04 Quite Low
Pain 1 25.00 Low Low
agonist 8 19.52 Low Low
interneuron 4 9.64 Low Low
Disease Link Frequency Relevance Heat
Nociception 4 99.16 Very High Very High Very High
Ganglion Cysts 5 88.16 High High
Vibrio Infection 2 79.36 Quite High
Toxicity 2 67.72 Quite High
Repression 2 26.72 Quite Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Phototoxic Dermatitis 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that the suppression of nAChR gene expression by muscle activity can be reversed by increasing intracellular cAMP levels.
Negative_regulation (reversed) of Gene_expression (expression) of nAChR gene in muscle
1) Confidence 0.52 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.16
We report here that the suppression of nAChR gene expression by muscle activity can be reversed by increasing intracellular cAMP levels.
Negative_regulation (suppression) of Gene_expression (expression) of nAChR gene in muscle
2) Confidence 0.38 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.15
The differences in these nAChR-mediated effects could be related to the expression of different nAChR subtypes located on nociceptive neurons.
Negative_regulation (related) of Gene_expression (expression) of nAChR in neurons associated with nociception
3) Confidence 0.27 Published 2004 Journal Auton Neurosci Section Abstract Doc Link 15296793 Disease Relevance 0.39 Pain Relevance 0.13
These myotubes, when stimulated with extracellular electrodes, suppressed endogenous embryonic-type nAChR gene expression compared to those treated with TTX.
Negative_regulation (suppressed) of Gene_expression (expression) of nAChR gene in myotubes associated with tetrodotoxin
4) Confidence 0.19 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.29
Muscle electrical activity suppresses expression of the embryonic-type (alpha, beta, gamma, and delta) nicotinic acetylcholine receptor (nAChR) genes.
Negative_regulation (suppresses) of Gene_expression (expression) of nAChR in Muscle
5) Confidence 0.16 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.05
7-nAChR clusters were not disrupted upon depolymerization of actin filaments and microtubules, whereas ?
Neg (not) Negative_regulation (disrupted) of Gene_expression (clusters) of nAChR in filaments
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0.24 Pain Relevance 0.03
7-nAChR mobility is reduced in ?
Negative_regulation (reduced) of Gene_expression (mobility) of nAChR
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.07

General Comments

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