INT12272

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Context Info
Confidence 0.33
First Reported 1992
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.04
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
lymph node 2
Muscle 2
brain 2
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
Sciatic nerve 2 95.84 Very High Very High Very High
anesthesia 1 95.40 Very High Very High Very High
Spinal cord 2 95.12 Very High Very High Very High
Nicotine 7 94.56 High High
tolerance 3 92.40 High High
Neuritis 2 77.72 Quite High
Somatosensory cortex 1 76.08 Quite High
tetrodotoxin 3 50.16 Quite High
cerebral cortex 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Brain Injury 7 99.38 Very High Very High Very High
Disease 1 92.36 High High
Cognitive Disorder 4 91.84 High High
Immunization 2 88.08 High High
Experimental Autoimmune Neuritis 1 77.72 Quite High
Injury 4 77.20 Quite High
Multiple Sclerosis 2 76.48 Quite High
Experimental Autoimmune Myasthenia Gravis 4 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies from our laboratory have shown that experimental rat brain injury causes a rapid and persistent decrease in CNS alpha7* nicotinic cholinergic receptor (nAChr) expression.
Negative_regulation (decrease) of Gene_expression (expression) of nAChr in brain associated with brain injury
1) Confidence 0.33 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 0.90 Pain Relevance 0.28
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Negative_regulation (suppressed) of Gene_expression (expression) of AChR in lymph node associated with necrosis, cancer, tolerance and cytokine
2) Confidence 0.32 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.14 Pain Relevance 0.49
Muscle electrical activity suppresses expression of the embryonic-type (alpha, beta, gamma, and delta) nicotinic acetylcholine receptor (nAChR) genes.
Negative_regulation (suppresses) of Gene_expression (expression) of nicotinic acetylcholine receptor in Muscle
3) Confidence 0.25 Published 1992 Journal Development Section Abstract Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.05

General Comments

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