INT122725

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.74
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
colon 1
PGE2 1
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 45 95.92 Very High Very High Very High
agonist 134 82.16 Quite High
withdrawal 35 80.52 Quite High
Dismenorea 6 75.00 Quite High
Potency 20 73.24 Quite High
Inflammatory stimuli 3 69.28 Quite High
antagonist 36 61.52 Quite High
addiction 5 50.32 Quite High
cytokine 7 33.76 Quite Low
cINOD 37 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 320 99.84 Very High Very High Very High
Disease 16 99.68 Very High Very High Very High
INFLAMMATION 68 95.92 Very High Very High Very High
Hypertrophy 22 92.84 High High
Nasal Polyps 24 86.72 High High
Chronic Sinusitis 24 86.08 High High
Dysmenorrhea 6 75.00 Quite High
Rhinitis 16 50.00 Quite Low
Apoptosis 85 46.76 Quite Low
Polyps 3 38.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, EP3 receptor levels are down regulated in colon cancer mucosa in comparison to healthy tissue [26], indicating that EP3 expression may not be compatible with a high proliferative rate in those cells.
Regulation (regulated) of EP3 in colon associated with colon cancer
1) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.52 Pain Relevance 0.04
In particular, the possibility that different concentrations and/or batches of serum may affect EP3 receptor subtype levels to different extents is a factor that could have a large impact on the responsiveness of CRC cell lines to PGE2.
Spec (may) Regulation (affect) of EP3 associated with colon cancer
2) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.10 Pain Relevance 0
One parameter worth considering at this point is the regulation of the EP3 receptor by serum, as documented in the current study.
Regulation (regulation) of EP3
3) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.03
Gi-coupled EP3 receptor splice variants are specifically regulated by serum
Regulation (regulated) of EP3
4) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.14
We further document that expression of Gi-coupled but not Gs/Gq-coupled EP3 splice variants is selectively up regulated following serum deprivation, indicating that cAMP-reducing EP3 receptor variants are regulated by the proliferative vs. quiescent status of the CRC cell.
Regulation (regulated) of EP3 associated with colon cancer
5) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.44 Pain Relevance 0.04
However, this is in contradiction with our results where EP1 and EP3 are down- regulated in the disease groups.
Regulation (regulated) of EP3 associated with disease
6) Confidence 0.11 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.23 Pain Relevance 0.30
Prostaglandin E2 (PGE2) exerts its biological effects through 4 different receptor subtypes, EP-1, EP-2, EP-3, and EP-4.
Regulation (effects) of EP-3 in PGE2
7) Confidence 0.01 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15519499 Disease Relevance 0.14 Pain Relevance 0.18
Contrary to our initial hypothesis, however, our findings reveal that AA did not affect chronic FP and/or EP3 receptor densities.
Neg (not) Regulation (affect) of EP3 receptor
8) Confidence 0.01 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.23 Pain Relevance 0

General Comments

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