INT12273

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.40
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
muscle 2
spinal 1
dorsal 1
muscle cell 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 8 100.00 Very High Very High Very High
antagonist 12 99.96 Very High Very High Very High
agonist 27 99.64 Very High Very High Very High
tetrodotoxin 14 97.52 Very High Very High Very High
Morphine 4 97.36 Very High Very High Very High
Dopamine 8 97.28 Very High Very High Very High
conotoxin 2 96.54 Very High Very High Very High
addiction 3 96.20 Very High Very High Very High
noradrenaline 14 96.00 Very High Very High Very High
antinociception 1 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paralysis 3 92.12 High High
Opiate Addiction 1 90.16 High High
Bordatella Infection 11 71.28 Quite High
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Glioma 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Acute Coronary Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that neither muscle activity nor innervation alone, but a combination of both, is required for full regulation of AChR antigenicity.
Regulation (regulation) of AChR in muscle
1) Confidence 0.59 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2293108 Disease Relevance 0.24 Pain Relevance 0.31
Nicotinic acetylcholine receptor regulation of spinal norepinephrine release.
Regulation (regulation) of Nicotinic acetylcholine receptor in spinal
2) Confidence 0.45 Published 2002 Journal Anesthesiology Section Title Doc Link 12170059 Disease Relevance 0 Pain Relevance 0.36
The effects of the nicotinic acetylcholine receptor (nAChR) agonist epibatidine on the extracellular concentrations of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dorsal (caudate-putamen) and the ventral striatum (nucleus accumbens) of freely-moving male Wistar rats were studied by in vivo microdialysis.
Regulation (effects) of nicotinic acetylcholine receptor in dorsal associated with nucleus accumbens, dopamine and agonist
3) Confidence 0.45 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11111841 Disease Relevance 0 Pain Relevance 0.33
Effects of alpha4beta2 and alpha7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats.
Regulation (Effects) of nicotinic acetylcholine receptor associated with antagonist, narcan and morphine
4) Confidence 0.39 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16098507 Disease Relevance 0.09 Pain Relevance 0.95
Nifedipine failed to prevent the dimethylphenylpiperazinium-induced release of [3H]noradrenaline, but Cd2+, omega-conotoxin and Ca(2+)-free conditions significantly reduced the dimethylphenylpiperazinium-induced release, suggesting that N-type voltage-sensitive Ca2+ channels are involved in the nicotinic acetylcholine receptor response.
Regulation (response) of nicotinic acetylcholine receptor associated with noradrenaline and conotoxin
5) Confidence 0.16 Published 1997 Journal Neuroscience Section Abstract Doc Link 9044380 Disease Relevance 0 Pain Relevance 0.72
A 102 base pair sequence of the nicotinic acetylcholine receptor delta-subunit gene confers regulation by muscle electrical activity.
Regulation (regulation) of nicotinic acetylcholine receptor in muscle
6) Confidence 0.13 Published 1992 Journal Development Section Title Doc Link 1638981 Disease Relevance 0 Pain Relevance 0.20
Embryonic chick muscle cell cultures treated with the muscle activity blocking agents decamethonium (DCM), d-tubocurare (TBC), and tetrodotoxin (TTX) or co-cultured with cholinergic neurons were examined for the influence of muscle activity on nuclear aggregation and its effects on AChR alpha-, gamma-, and delta-subunit message expression. mRNA was measured by in situ hybridization and nuclei were visualized by bis-benzimide DNA staining.
Regulation (effects) of AChR in muscle cell associated with tetrodotoxin
7) Confidence 0.06 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.19
The nicotinic acetylcholine receptor as a prototypical ligand-gated ion channel has been shown to be modulated via a variety of G protein-coupled receptors, and receptor activation was found to either enhance or reduce the function of that ion channel [69–73].
Regulation (modulated) of nicotinic acetylcholine receptor
8) Confidence 0.02 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.07 Pain Relevance 0.14

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