INT122775

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.72
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) cell proliferation (Gdnf) extracellular space (Gdnf)
extracellular region (Gdnf) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
glial cell 2
IB4 2
Gdnf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 105 100.00 Very High Very High Very High
Inflammation 27 99.84 Very High Very High Very High
nociceptor 13 99.84 Very High Very High Very High
Thermal hyperalgesia 12 98.04 Very High Very High Very High
Pain 7 97.72 Very High Very High Very High
bradykinin 1 96.16 Very High Very High Very High
Inflammatory mediators 1 94.68 High High
addiction 2 93.40 High High
qutenza 81 93.24 High High
trigeminal ganglion 59 86.80 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 12 98.92 Very High Very High Very High
INFLAMMATION 21 98.56 Very High Very High Very High
Hyperalgesia 18 98.04 Very High Very High Very High
Pain 10 97.72 Very High Very High Very High
Ganglion Cysts 73 86.80 High High
Drug Induced Neurotoxicity 2 75.56 Quite High
Neuropathic Pain 7 68.00 Quite High
Toxicity 4 57.88 Quite High
Headache 6 47.00 Quite Low
Disease 2 43.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia.
GDNF Regulation (regulate) of Gene_expression (expression) of TRPV1 associated with inflammation and thermal hyperalgesia
1) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15525272 Disease Relevance 0.75 Pain Relevance 0.90
Rat dorsal root ganglia (DRG) neurons were classified according to immunostaining for trk-A and IB4 and the effects of antibodies against NGF or GDNF on TRPV1 expression within the groups were then analysed by immunohistochemical means.
GDNF Regulation (effects) of Gene_expression (expression) of TRPV1 in IB4
2) Confidence 0.26 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.73 Pain Relevance 0.54
NGF, GDNF or BDNF (100 ng/ml) did not significantly alter TRPV1 mRNA levels after 5 days of treatment (Fig. 4).
GDNF Neg (not) Regulation (alter) of Gene_expression (levels) of TRPV1 mRNA associated with nerve growth factor
3) Confidence 0.21 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.20 Pain Relevance 0.28
The sensitivity and expression of TRPV1 is modulated by the neurotrophins nerve growth factor (NGF) [23-25] and glial cell-line derived neurotrophic factor (GDNF) in rodents [26] and humans [27].
GDNF Regulation (modulated) of Gene_expression (expression) of TRPV1 in glial cell associated with nerve growth factor
4) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 1.04 Pain Relevance 0.70

General Comments

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