INT122776

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.13
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) cell proliferation (Gdnf) extracellular space (Gdnf)
extracellular region (Gdnf) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 4
Gdnf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 104 100.00 Very High Very High Very High
dorsal root ganglion 24 99.80 Very High Very High Very High
Inflammation 22 99.22 Very High Very High Very High
Neuropeptide 22 99.08 Very High Very High Very High
Thermal hyperalgesia 10 98.48 Very High Very High Very High
intrathecal 2 94.48 High High
Nerve growth factor 200 93.80 High High
c fibre 2 90.72 High High
substance P 10 88.64 High High
trigeminal ganglion 118 81.08 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 146 99.80 Very High Very High Very High
INFLAMMATION 17 99.22 Very High Very High Very High
Hyperalgesia 18 98.48 Very High Very High Very High
Nociception 16 96.44 Very High Very High Very High
Hypersensitivity 4 74.80 Quite High
Injury 46 73.76 Quite High
Nervous System Injury 4 45.84 Quite Low
Pain 6 12.56 Low Low
Headache 12 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that inflammation differentially increases both NGF and GDNF, which facilitate TRPV1 expression within distinctive neurons to induce thermal hyperalgesia.
GDNF Positive_regulation (facilitate) of Gene_expression (expression) of TRPV1 in neurons associated with inflammation and thermal hyperalgesia
1) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.82 Pain Relevance 0.58
In cultured DRG neurons, GDNF increases CAP sensitivity and TRPV1 expression [16,26] and increases neuropeptide content [16].
GDNF Positive_regulation (increases) of Gene_expression (expression) of TRPV1 in neurons associated with dorsal root ganglion, qutenza and neuropeptide
2) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.84 Pain Relevance 1.62
Interestingly, the study by Bron et al. (2003) indicated that GDNF is also able to upregulate TRPV1 expression; although this conclusion was based on immunofluorescence and cobalt uptake assays, it is consistent with our direct demonstration of GDNF-induced upregulation of TRPV1 protein by Western blot.
GDNF Positive_regulation (upregulate) of Gene_expression (expression) of TRPV1
3) Confidence 0.38 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.48 Pain Relevance 0.85

General Comments

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