INT122779

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Context Info
Confidence 0.74
First Reported 2004
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 4.31
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) signal transduction (Ngf) extracellular space (Ngf)
aging (Ngf) extracellular region (Ngf) plasma membrane (Trpv1)
Anatomy Link Frequency
sensory neurons 4
nerve 2
neurons 2
dorsal root ganglion 2
Ngf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 252 100.00 Very High Very High Very High
qutenza 105 100.00 Very High Very High Very High
Inflammation 42 99.38 Very High Very High Very High
Thermal hyperalgesia 10 98.48 Very High Very High Very High
Root ganglion neuron 5 97.88 Very High Very High Very High
Eae 2 93.92 High High
Hyperalgesia 11 92.40 High High
Calcitonin gene-related peptide 192 88.32 High High
substance P 15 87.92 High High
Neuropeptide 23 86.32 High High
Disease Link Frequency Relevance Heat
Nociception 29 100.00 Very High Very High Very High
Pheochromocytoma 5 99.48 Very High Very High Very High
INFLAMMATION 33 99.38 Very High Very High Very High
Hyperalgesia 23 98.48 Very High Very High Very High
Ganglion Cysts 151 97.68 Very High Very High Very High
Injury 52 93.92 High High
Hypersensitivity 7 82.92 Quite High
Pain 36 82.24 Quite High
Neuropathic Pain 16 69.52 Quite High
Attention Deficit Hyperactivity Disorder 2 34.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that inflammation differentially increases both NGF and GDNF, which facilitate TRPV1 expression within distinctive neurons to induce thermal hyperalgesia.
NGF Positive_regulation (facilitate) of Gene_expression (expression) of TRPV1 in neurons associated with inflammation and thermal hyperalgesia
1) Confidence 0.74 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.82 Pain Relevance 0.59
Nerve growth factor (NGF) regulates the nociceptive properties of a subset of small diameter sensory neurons by increasing the expression of the heat-sensing transient receptor potential (TRP) channel, TRPV1.
NGF Positive_regulation (increasing) of Gene_expression (expression) of TRPV1 in sensory neurons associated with nociception and nerve growth factor
2) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.25 Pain Relevance 0.27
Nerve growth factor (NGF) regulates the nociceptive properties of a subset of small diameter sensory neurons by increasing the expression of the heat-sensing transient receptor potential (TRP) channel, TRPV1.
Nerve growth factor Positive_regulation (increasing) of Gene_expression (expression) of TRPV1 in sensory neurons associated with nociception and nerve growth factor
3) Confidence 0.64 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.25 Pain Relevance 0.27
In accordance with this increased CAP sensitivity, NGF increases the expression of the CAP- and noxious heat-sensitive ion channel vanilloid receptor type 1 (TRPV1) through the ras/p38 MAP kinase signaling pathway, thereby promoting thermal hyperalgesia [25,26].
NGF Positive_regulation (increases) of Gene_expression (expression) of vanilloid receptor type 1 associated with nerve growth factor, qutenza and thermal hyperalgesia
4) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.90 Pain Relevance 1.55
In accordance with this increased CAP sensitivity, NGF increases the expression of the CAP- and noxious heat-sensitive ion channel vanilloid receptor type 1 (TRPV1) through the ras/p38 MAP kinase signaling pathway, thereby promoting thermal hyperalgesia [25,26].
NGF Positive_regulation (increases) of Gene_expression (expression) of TRPV1 associated with nerve growth factor, qutenza and thermal hyperalgesia
5) Confidence 0.49 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.90 Pain Relevance 1.55
In this study, we determined whether the NADPH oxidase pathway is involved in NGF-stimulated TRPV1 expression using a rat pheochromocytoma 12 line and rat dorsal root ganglion neurons.
NGF-stimulated Spec (whether) Positive_regulation (stimulated) of Gene_expression (expression) of TRPV1 in dorsal root ganglion associated with ganglion cysts, nerve growth factor, root ganglion neuron and pheochromocytoma
6) Confidence 0.46 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.28 Pain Relevance 0.33
Inhibition of NADPH oxidase by transient transfection of a dominant negative Rac1 mutant (RacN17) plasmid blocked NGF-stimulated TRPV1 protein expression, while expression of a constitutively active Rac1 increased basal and NGF-stimulated TRPV1 levels.
NGF-stimulated Positive_regulation (stimulated) of Gene_expression (expression) of TRPV1 associated with nerve growth factor
7) Confidence 0.46 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.22 Pain Relevance 0.48
Essential role of Rac1/NADPH oxidase in nerve growth factor induction of TRPV1 expression.
nerve growth factor Positive_regulation (induction) of Gene_expression (expression) of TRPV1 in nerve associated with nerve growth factor
8) Confidence 0.43 Published 2005 Journal J. Neurochem. Section Title Doc Link 16283857 Disease Relevance 0.25 Pain Relevance 0.38
Furthermore, ERK inhibition has been shown to partially reduce the upregulation of TRPV1 expression induced by NGF.
NGF Positive_regulation (induced) of Gene_expression (expression) of TRPV1 associated with nerve growth factor
9) Confidence 0.43 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.44 Pain Relevance 0.68

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