INT122782

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
brains 2
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 17 100.00 Very High Very High Very High
Nicotine 14 98.48 Very High Very High Very High
Neuropeptide 8 98.40 Very High Very High Very High
dorsal root ganglion 1 93.80 High High
Spinal cord 4 92.60 High High
Dorsal horn 1 88.64 High High
antinociception 5 86.40 High High
intrathecal 1 84.36 Quite High
narcan 2 82.40 Quite High
Ventral tegmentum 1 67.00 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 6 99.76 Very High Very High Very High
Targeted Disruption 6 99.58 Very High Very High Very High
Ganglion Cysts 1 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in ppENK mRNA level was inhibited by MEC (3 mg/kg, s.c.).
Negative_regulation (inhibited) of Positive_regulation (increase) of ENK
1) Confidence 0.57 Published 2008 Journal Brain Res. Section Abstract Doc Link 18048009 Disease Relevance 0.09 Pain Relevance 1.56
The processing of proenkephalin was impaired in PC1 KO mouse brains with a decrease in the level of Met-Enkephalin immunoreactivity (ir-Met-Enk) and an accumulation of higher molecular weight processing intermediates containing ir-Met-Enk.
Negative_regulation (decrease) of Positive_regulation (accumulation) of Enk in brains associated with targeted disruption and enkephalin
2) Confidence 0.41 Published 2005 Journal Biochemistry Section Abstract Doc Link 15779921 Disease Relevance 0.52 Pain Relevance 0.32
In the BLA and CEA, 'high-anxiety' mice also displayed increased FRA/ENK after TMT exposure and LD testing.
Negative_regulation (displayed) of Positive_regulation (increased) of ENK associated with anxiety disorder and enkephalin
3) Confidence 0.41 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.53 Pain Relevance 0.92

General Comments

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