INT122783

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
alcohol 2 98.68 Very High Very High Very High
Nucleus accumbens 1 80.80 Quite High
Physical dependence 1 80.00 Quite High
Ventral tegmentum 1 79.28 Quite High
withdrawal 2 56.08 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 80.00 Quite High
Anxiety Disorder 6 75.00 Quite High
Alcohol Addiction 1 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged alcohol drinking can perturb aspects of this system, including a loss of control of Met-enkephalin levels at the transcriptional and translational levels, and impaired release of Met-enkephalin from tissue sources.
Regulation (control) of Transcription (transcriptional) of Met-enkephalin associated with enkephalin and alcohol
1) Confidence 0.20 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.14 Pain Relevance 0.67
The present study assessed alterations in mesolimbic enkephalin (ENK) mRNA levels after predator [2,5-dihydro-2,4,5-trimethylethiazoline (TMT)] and non-predator (butyric acid) odor encounter and/or light-dark (LD) testing in CD-1 mice immediately, 24, 48 and 168 h after the initial odor encounter and/or LD testing.
Regulation (alterations) of Transcription (levels) of enkephalin associated with enkephalin
2) Confidence 0.03 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.07 Pain Relevance 0.54

General Comments

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