INT122811

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 3.01
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ecd) nucleus (Ecd) cellular_component (Ecd)
cytoplasm (Ecd)
Anatomy Link Frequency
sensory neurons 1
Ecd (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 2 99.32 Very High Very High Very High
agonist 126 94.48 High High
Pain 15 92.88 High High
alcohol 14 82.72 Quite High
cva 3 79.68 Quite High
depression 22 72.76 Quite High
ischemia 27 71.32 Quite High
Angina 1 68.08 Quite High
Nicotine 37 51.36 Quite High
imagery 26 45.36 Quite Low
Disease Link Frequency Relevance Heat
Disease 24 100.00 Very High Very High Very High
Fibrosis 2 99.32 Very High Very High Very High
Pathologic Constriction 9 97.24 Very High Very High Very High
Pain 15 92.88 High High
Acute Coronary Syndrome 7 85.56 High High
Myocardial Infarction 15 85.24 High High
Necrosis 2 84.64 Quite High
Shock 42 83.28 Quite High
Histiocytosis 1 82.52 Quite High
Cv General 3 Under Development 2 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report 6 new cases of ECD associated with periaortic fibrosis.
ECD Binding (associated) of associated with fibrosis and disease
1) Confidence 0.31 Published 2004 Journal Medicine (Baltimore) Section Abstract Doc Link 15525849 Disease Relevance 1.36 Pain Relevance 0.18
Filter assay demonstrated that increasing concentrations of [3H]deoxygedunin progressively bound TrkB ECD but not ICD, indicating that TrkB ECD but not ICD selectively binds deoxygedunin.
ECD Binding (bound) of
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Filter assay demonstrated that increasing concentrations of [3H]deoxygedunin progressively bound TrkB ECD but not ICD, indicating that TrkB ECD but not ICD selectively binds deoxygedunin.
ECD Binding (binds) of
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Conceivably, these two compounds share the same binding pocket on TrkB ECD.
ECD Binding (binding) of
4) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.07 Pain Relevance 0.15
Conceivably, these two compounds share the same binding pocket on TrkB ECD.
ECD Binding (pocket) of
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.07 Pain Relevance 0.15
Deoxygedunin might bind to different motif on TrkB ECD from that of 7,8-DHF and NAS.
ECD Spec (might) Binding (bind) of
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
Deoxygedunin binds TrkB ECD and provokes its dimerization
ECD Binding (binds) of
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Hence, deoxygedunin directly binds TrkB ECD and triggers its association.
ECD Binding (binds) of
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.06 Pain Relevance 0
Collectively, these results indicate that in sensory neurons, Type III Nrg1, acting as a receptor for B4-ECD, regulates the surface expression of ?
B4-ECD Binding (receptor) of in sensory neurons
9) Confidence 0.07 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
7* nAChR clusters induced by B4-ECD treatment were localized in close proximity to membrane-bound B4-ECD (Fig. 2 D).
B4-ECD Binding (bound) of
10) Confidence 0.07 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
After a 24-h treatment with B4-ECD, we observed an ?
B4-ECD Binding (treatment) of
11) Confidence 0.06 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
ECD findings were classified as stenotic or occlusive if ECD showed at least one stenosis ?
ECD Binding (findings) of associated with pathologic constriction
12) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906428 Disease Relevance 1.37 Pain Relevance 0.21

General Comments

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