INT122812
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Only within the part of SCC, were neuroendocrine (NE) markers (chromogranin A [CgA], NCAM, and synaptophysin [SNP]) expressed. | |||||||||||||||
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In contrast, htSNPs of the ten transporter genes as well as the three nuclear receptor genes under study were equally distributed, confirming previous studies of htSNPs in key transporters without major impact [1, 113, 114]. | |||||||||||||||
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In particular, the associations between SNP rs324987 and ACPA-negative RA (p? | |||||||||||||||
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In particular, while an association signal of nominal significance is observed for several markers spread over half of the gene (110 kb from intron 2 through exon 9), best statistical evidence withstanding correction for multiple tests was obtained for SNPs rs324987 and rs10263447. | |||||||||||||||
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Based on the above sequencing data, linkage disequilibrium analysis results showed that all detected SNPs located in the same haploblock (Figure 1). | |||||||||||||||
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0.0044), and SNP rs10263447 and DAS28 (p? | |||||||||||||||
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The distributions of SNPs rs2236659, rs2276077, rs10892958 and rs1461496 did not depart from the Hardy-Weinberg equilibrium in control group (P? | |||||||||||||||
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In SLE this SNP and two other linked SNPs, the SNPs rs2070197 in the 3? | |||||||||||||||
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Linkage disequilibrium mapping of AGTR1 and ALOX15 in these analyses suggests that regions near to tagSNPs rs6801836 on AGTR1 and rs2664593 on ALOX15 are responsible for the interactions seen in this study. | |||||||||||||||
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For each region on SSC1 only 1-4 SNPs pass the significance level, whereas on SSC6 a total of 31 highly significant SNPs are detected. | |||||||||||||||
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0.674 (95% CI 0.5120.888)] and that of SNP rs10263447 with DAS28 [p? | |||||||||||||||
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In analysis of the SNPs, rs4570625 and rs456946 of TPH2, they found a significant preferential transmission of haplotype G-C to OCD. | |||||||||||||||
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Genotypes of the three LOXL1 SNPs were determined by direct DNA sequencing, using BigDye Terminator v3.1 Kit (Applied Biosystems, Foster City, CA) in a 3730XL capillary sequencer (Applied Biosystems). | |||||||||||||||
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For the SNPs rs3825942 and rs2165241, three haplotypes were observed, with the haplotype G-C being at a significantly higher frequency in cases than in controls (p=0.002, OR=12.18, 95% CI: 1.6192.09). | |||||||||||||||
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Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R. | |||||||||||||||
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As brain 5-HT biosynthesis is regulated by TPH2 [6], [26], and TPH2 SNPs increase the risk for psychiatric disorders [27], [28], [29], we decided to further analyze the polymorphic variability of the human TPH2 gene and focused on its coding region. | |||||||||||||||
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Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R. | |||||||||||||||
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Interestingly, the SNP rs324987 that associates with ACPA-negative RA in this study is in strong LD (r2? | |||||||||||||||
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Although our current study does not allow us to pinpoint which of these three USF1 SNPs in LD is the actual causative SNP, we were able to demonstrate that an allele-dependent effect of the rs3737787 tagged LD bin on downstream genes is mediated by USF1 and not the adjacent gene F11R. | |||||||||||||||
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They also found a trend of preferential transmission of the C allele of SNP rs4565946 to the early-onset of OCD.
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