INT122823

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) helicase activity (ERCC2)
Anatomy Link Frequency
SH-SY5Y 1
EM-2 1
ERCC2 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
antagonist 1 61.60 Quite High
agonist 1 39.76 Quite Low
MU agonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human neuroblastoma cell line, SH-SY5Y, was used to examine the effects of morphine and the endogenous opioid peptides, endomorphin-1 (EM-1) and endomorphin-2 (EM-2), on mu opioid receptor (MOR) internalization and down-regulation.
EM-2 Spec (examine) Regulation (effects) of in SH-SY5Y Negative_regulation (down-regulation) of mu opioid receptor in EM-2 associated with neuroblastoma, mu opioid receptor, endogenous opioid and morphine
1) Confidence 0.23 Published 2004 Journal Brain Res. Section Abstract Doc Link 15527737 Disease Relevance 0.17 Pain Relevance 0.63

General Comments

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