INT122880

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.89
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
sensory neuron 1
nociceptors 1
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 37 99.92 Very High Very High Very High
trigeminal ganglion 77 99.70 Very High Very High Very High
dorsal root ganglion 55 97.60 Very High Very High Very High
Neurotransmitter 7 50.00 Quite Low
Glutamate 117 45.28 Quite Low
Hippocampus 24 40.00 Quite Low
qutenza 1 34.80 Quite Low
Acute pain 1 21.16 Low Low
Serotonin 2 10.32 Low Low
Spinal cord 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 145 99.70 Very High Very High Very High
Targeted Disruption 150 97.20 Very High Very High Very High
Nociception 30 79.28 Quite High
Adhesions 8 69.16 Quite High
Attention Deficit Hyperactivity Disorder 12 45.84 Quite Low
Frailty 1 36.00 Quite Low
Wiskott-aldrich Syndrome 1 32.64 Quite Low
Pain 7 21.16 Low Low
Congenital Anomalies 2 10.44 Low Low
Death 37 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The normal initial expression of TrkC in Brn3a-/- TG suggests that regulation of TrkC is a secondary effect.
Regulation (regulation) of TrkC associated with trigeminal ganglion
1) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.28 Pain Relevance 0.16
With regard to Necdin expression, we examined more closely the TrkA, TrkB and TrkC sensory neuron subpopulations.
Spec (examined) Regulation (subpopulations) of TrkC in sensory neuron
2) Confidence 0.42 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.08 Pain Relevance 0
The present study suggests that the development of myelinated nociceptors is dependent on trkA and trkC but not on trkB.
Neg (not) Regulation (dependent) of trkC in nociceptors associated with nociceptor
3) Confidence 0.39 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15530548 Disease Relevance 0.53 Pain Relevance 0.21
The genes for two cell surface receptors of BDNF, Ntrk2 and Ntrk3, were significantly up-regulated.
Regulation (regulated) of Ntrk3
4) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.23 Pain Relevance 0
Therefore, it is natural to infer that trkC is a transcriptional target of Runx3 [17].
Regulation (target) of trkC
5) Confidence 0.24 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.76 Pain Relevance 0.29

General Comments

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