INT122882

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 9.70
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
dorsal horn 4
neuronal 1
sensory neuron 1
primary neurons 1
hair cells 1
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 35 99.98 Very High Very High Very High
nociceptor 11 99.92 Very High Very High Very High
antidepressant 183 99.84 Very High Very High Very High
Dorsal horn 29 99.68 Very High Very High Very High
Root ganglion neuron 14 99.48 Very High Very High Very High
Inflammation 81 98.92 Very High Very High Very High
sSRI 93 98.40 Very High Very High Very High
Eae 24 96.00 Very High Very High Very High
depression 186 95.92 Very High Very High Very High
Neuropathic pain 28 94.44 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 52 99.16 Very High Very High Very High
INFLAMMATION 91 98.92 Very High Very High Very High
Neurological Disease 10 98.36 Very High Very High Very High
Affective Disorder 12 98.20 Very High Very High Very High
Targeted Disruption 168 97.60 Very High Very High Very High
Stroke 8 96.24 Very High Very High Very High
Depression 236 95.92 Very High Very High Very High
Anxiety Disorder 58 95.44 Very High Very High Very High
Neuropathic Pain 49 94.44 High High
Manic Depressive Disorder 5 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since trkB.T1 and trkB.FL are presumably regulated by a common promoter, we also undertook a careful examination of spinal dorsal horn trkB.FL mRNA and protein regulation in the antiretroviral and inflammatory models in both wildtype and trkB.T1 knockout animals.
Regulation (regulated) of trkB in dorsal horn associated with targeted disruption, inflammation and spinal dorsal horn
1) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 1.08 Pain Relevance 0.43
Since trkB.T1 and trkB.FL are presumably regulated by a common promoter, we also undertook a careful examination of spinal dorsal horn trkB.FL mRNA and protein regulation in the antiretroviral and inflammatory models in both wildtype and trkB.T1 knockout animals.
Regulation (regulated) of trkB in dorsal horn associated with targeted disruption, inflammation and spinal dorsal horn
2) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 1.07 Pain Relevance 0.43
Next, we asked whether trkB.T1 protein was regulated in the dorsal horn after treatment.
Spec (whether) Regulation (regulated) of trkB in dorsal horn associated with dorsal horn
3) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.50 Pain Relevance 0.41
As demonstrated in Additional File 1, we detected no significant regulation of trkB.FL mRNA (panels A-D) following antiretroviral or inflammatory treatment compared with vehicle controls in either genotype.
Neg (no) Regulation (regulation) of trkB associated with inflammation
4) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.85 Pain Relevance 0.41
It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning.
Regulation (modulation) of Trkb
5) Confidence 0.59 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2732010 Disease Relevance 1.13 Pain Relevance 0.30
Thus, we conclude that the up-regulation of trkB.T1 following noxious stimulation is specific for this isoform.
Regulation (regulation) of trkB
6) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.81 Pain Relevance 0.40
In Figure 1B, we demonstrate that trkB.T1 protein is significantly up-regulated one day after d4T injection compared with saline control-injected animals.
Regulation (regulated) of trkB
7) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.59 Pain Relevance 0.45
This phenotype results in impaired balance in TrkbPLC/PLC mutants compared to control mice.
Regulation (control) of TrkbPLC
8) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.08 Pain Relevance 0.07
In particular, we show that while the growth of vestibular afferents to inner ear sensory epithelia are unaffected in TrkBPLC mutants, these fibers run along the peripheral margin of the sensory epithelia without taking sharp turns to innervate their specific hair cells as in control mice (Fig. 5,6).
Neg (unaffected) Regulation (unaffected) of TrkBPLC in hair cells
9) Confidence 0.45 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0
The present study suggests that the development of myelinated nociceptors is dependent on trkA and trkC but not on trkB.
Neg (not) Regulation (dependent) of trkB in nociceptors associated with nociceptor
10) Confidence 0.41 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15530548 Disease Relevance 0.53 Pain Relevance 0.21
With regard to Necdin expression, we examined more closely the TrkA, TrkB and TrkC sensory neuron subpopulations.
Spec (examined) Regulation (subpopulations) of TrkB in sensory neuron
11) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.08 Pain Relevance 0
Since trkB.T1 and trkB.FL are presumably regulated by a common promoter, we also undertook a careful examination of spinal dorsal horn trkB.FL mRNA and protein regulation in the antiretroviral and inflammatory models in both wildtype and trkB.T1 knockout animals.
Spec (examination) Regulation (regulation) of trkB in dorsal horn associated with targeted disruption, inflammation and spinal dorsal horn
12) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.99 Pain Relevance 0.38
The second round screening in primary neurons and follow-up TrkB association and autophosphorylation analyses eliminate compounds that did not directly target TrkB receptor.
Neg (not) Regulation (target) of TrkB in primary neurons
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.46 Pain Relevance 0.12
BDNF and TrkB receptor are targets for therapeutic intervention in various neurological diseases including neuroexcitotoxicity, stroke, depression, anxiety, neurodegeneration etc.
Regulation (targets) of TrkB associated with neurological disease, depression, stroke and anxiety disorder
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.59 Pain Relevance 0.17
Plasmin is the major extracellular protease that cleaves pro-BDNF.60,61 The expression of the BDNF gene is tightly regulated by neuronal activity, through mechanisms dependent on calcium.62 In addition to BDNF, the function of a receptor for BDNF (ie, TrkB) is also regulated in an activity-dependent manner.
Regulation (regulated) of TrkB in neuronal
15) Confidence 0.26 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.12 Pain Relevance 0.03
The genes for two cell surface receptors of BDNF, Ntrk2 and Ntrk3, were significantly up-regulated.
Regulation (regulated) of Ntrk2
16) Confidence 0.11 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.23 Pain Relevance 0
The receptor for BDNF is trkB (troponin/receptor kinase B), which is affected by antidepressant treatment, including SSRIs, and appears to be necessary for antidepressant effects (Rumajogee et al 2002; Saarelainen et al 2003).
Regulation (affected) of trkB associated with antidepressant and ssri
17) Confidence 0.08 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.58 Pain Relevance 0.47

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