INT122888

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.51
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mononuclear cell 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 10 99.30 Very High Very High Very High
cytokine 97 98.72 Very High Very High Very High
Sciatic nerve 1 94.28 High High
Inflammation 78 91.24 High High
Peripheral nervous system 1 88.92 High High
adenocard 1 70.96 Quite High
Central nervous system 7 63.96 Quite High
Inflammatory mediators 4 63.32 Quite High
chemokine 2 61.48 Quite High
cINOD 6 60.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 40 99.64 Very High Very High Very High
Necrosis 11 99.40 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.30 Very High Very High Very High
Colitis 32 96.20 Very High Very High Very High
Hepatitis C Virus Infection 72 94.32 High High
Infection 239 93.40 High High
INFLAMMATION 83 91.24 High High
Syndrome 1 91.20 High High
Demyelinating Disease 1 87.60 High High
Death 8 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.
Positive_regulation (detect) of Transcription (expression) of IFN in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
1) Confidence 0.45 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.12 Pain Relevance 1.00
RIG-1 is activated by the binding of viral RNA, which enables RIG-1 to bind to IFN promoter stimulator 1(IPS-1) and trigger a signaling cascade that results in IFN transcription.
Positive_regulation (results) of Transcription (transcription) of IFN
2) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.49 Pain Relevance 0.14
Recently, it was found that miltefosine enhanced IFN-?
Positive_regulation (enhanced) of Transcription (found) of IFN
3) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.26 Pain Relevance 0.05
In the presence of high levels of IFN-?
Positive_regulation (levels) of Transcription (presence) of IFN
4) Confidence 0.06 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.45 Pain Relevance 0.03
DKO mice had significantly increased production of mRNA encoding TNF and interferon (IFN)-?
Positive_regulation (increased) of Transcription (production) of IFN
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 1.18 Pain Relevance 0.36

General Comments

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