INT122893

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.97
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pts) lyase activity (Pts) cytoplasm (Pts)
Anatomy Link Frequency
cartilage 1
Pts (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 1 100.00 Very High Very High Very High
depression 5 99.64 Very High Very High Very High
Dopamine 7 86.24 High High
dexamethasone 6 79.96 Quite High
Substantia nigra 3 77.76 Quite High
Neuropeptide 2 75.00 Quite High
dopamine receptor 1 75.00 Quite High
Nucleus accumbens 3 46.08 Quite Low
imagery 6 36.32 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 5 99.64 Very High Very High Very High
Dystonia 5 97.36 Very High Very High Very High
Toxicity 1 93.00 High High
Obesity 18 90.24 High High
Apoptosis 2 76.08 Quite High
Noise-induced Hearing Loss 26 73.76 Quite High
Tendinopathy 12 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Tendon Injuries 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not likely that this residual PTS is the result of administration of inadequate drug levels because injecting higher concentrations of furosemide does not produce greater depression of the endocochlear potential [18], and a greater number of NAC injections than used here was accompanied by less protection [2] and can lead to pulmonary toxicity [19].
Neg (not) Gene_expression (produce) of PTS associated with toxicity and depression
1) Confidence 0.10 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2936911 Disease Relevance 0.55 Pain Relevance 0.12
Similarly, cartilage-like pellets were not found and GAG-containing matrix was not detected by the staining of PTs or ATs (Figure 2J, K, N, O).
Gene_expression (staining) of PTs in cartilage
2) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0 Pain Relevance 0
PTs and ATs were grown in the same culture conditions as TSCs.
Gene_expression (grown) of PTs
3) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.09 Pain Relevance 0.10
The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans.
Gene_expression (biosynthesis) of tetrahydrobiopterin associated with tetrahydrobiopterin and dystonia
4) Confidence 0.02 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.33 Pain Relevance 0.39

General Comments

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