INT122895

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
striatum 2
nucleus accumbens 1
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 6 99.82 Very High Very High Very High
Dopamine 28 99.62 Very High Very High Very High
Nucleus accumbens 6 94.84 High High
Substantia nigra 6 91.00 High High
cocaine 2 81.60 Quite High
Tetrahydrobiopterin 2 78.56 Quite High
Neuropeptide 4 75.00 Quite High
dopamine receptor 3 75.00 Quite High
antagonist 3 69.20 Quite High
Glutamate 8 45.60 Quite Low
Disease Link Frequency Relevance Heat
Depression 5 99.82 Very High Very High Very High
Dystonia 13 96.56 Very High Very High Very High
Targeted Disruption 2 94.80 High High
Ataxia 73 5.00 Very Low Very Low Very Low
Cerebellar Ataxia 37 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low
Cerebellar Diseases 9 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 9 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
Neuropathy 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of D-2 in nucleus accumbens associated with nucleus accumbens and dopamine
1) Confidence 0.52 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.59
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Transcription (expression) of D-2 in striatum associated with nucleus accumbens and dopamine
2) Confidence 0.18 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.59
Extra-cellular dopamine levels are increased in the striatum, causing a depression in mRNA levels of both D1 and D2 receptors and decreased stores of dopamine [71, 96].
Transcription (levels) of D2 in striatum associated with dopamine and depression
3) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.19 Pain Relevance 0.54

General Comments

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