INT122901

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 67
Total Number 69
Disease Relevance 58.03
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
plasma 15
osteoblast 9
osteoclasts 3
T cells 2
synovial fluid 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 575 100.00 Very High Very High Very High
fibrosis 172 100.00 Very High Very High Very High
Multiple sclerosis 8 100.00 Very High Very High Very High
Neuritis 15 99.96 Very High Very High Very High
rheumatoid arthritis 23 97.64 Very High Very High Very High
Angina 13 96.60 Very High Very High Very High
chemokine 185 95.08 Very High Very High Very High
Inflammatory response 50 95.00 High High
Inflammatory mediators 4 94.24 High High
cytokine 528 93.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 513 100.00 Very High Very High Very High
Osteoporosis 511 100.00 Very High Very High Very High
Cardiovascular Disorder Under Development 112 100.00 Very High Very High Very High
Multiple Sclerosis 27 100.00 Very High Very High Very High
Targeted Disruption 808 99.96 Very High Very High Very High
Bacterial Infection 82 99.96 Very High Very High Very High
Experimental Autoimmune Neuritis 13 99.96 Very High Very High Very High
Osteogenic Sarcomas 5 99.86 Very High Very High Very High
Infection 624 99.84 Very High Very High Very High
Diabetes Mellitus 494 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, as many as 60–80% of ALD patients with an advanced stage of the disease have significantly increased levels of anti-phospholipid autoantibodies (aPL-Ab) that recognize oxidized cardiolipin and phosphatidylserine (reviewed in [249]). aPL-Ab, by recognizing and binding to specifically oxidized epitopes in apoptotic hepatocytes (not in living cells, with phosphatidylserine being oxidized during apoptosis and before exposure on plasma membranes), may affect the ability of Kupffer cells to recognize and phagocytose apoptotic cells.
Positive_regulation (increased) of aPL in apoptotic cells associated with alcoholic liver diseases, apoptosis and disease
1) Confidence 0.67 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.27 Pain Relevance 0.27
The presence of calcium nodules concomitant with the increase of ALP activity and the activation of the Opn gene showed that the respective cells had differentiated into matured osteoblasts.
Positive_regulation (activation) of Opn in osteoblasts
2) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.23 Pain Relevance 0
In this study, we showed that Opn and CatK genes were activated in the primary mononucleated cells that had been differentiated into osteoblasts and osteoclasts, respectively.
Positive_regulation (activated) of Opn in osteoclasts
3) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.42 Pain Relevance 0
Finally, the activation of the Opn gene in osteoblasts and CatK in osteoclasts supported the identification of each cell type.


Positive_regulation (activation) of Opn in osteoclasts
4) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.33 Pain Relevance 0
The activation of Opn demonstrates that the cells have differentiated into osteoblasts, while the activation of CatK indicates osteoclast differentiation.
Positive_regulation (activation) of Opn in osteoblasts
5) Confidence 0.65 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.39 Pain Relevance 0
In contrast, the studies in the Db cells demonstrate that overexpression of OPN alone is not sufficient to effect a metastatic phenotype, as evidenced by the lack of correlation between increased OPN levels and the metastasis rate in the Db-S cells.
Positive_regulation (increased) of OPN associated with metastasis
6) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.53 Pain Relevance 0
Zhang and colleagues [53] recently showed that the PI3-K/Akt axis activates OPN, which increases cell motility and anchorage independence.
Positive_regulation (activates) of OPN
7) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.44 Pain Relevance 0
Clinically, N-half OPN levels are elevated in the synovial fluid, urine, and plasma of patients with rheumatoid arthritis [7,27,35], as well as in the vitreous fluid of those with diabetic retinopathy [26], indicating that this cytokine is involved in local inflammation.
Positive_regulation (elevated) of OPN in plasma associated with inflammation, rheumatoid arthritis, diabetic retinopathy and cytokine
8) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.52 Pain Relevance 0.37
Microarray analyses of diabetic versus normal kidneys identified OPN as one of the major genes upregulated in humans with diabetic nephropathy and in mice with either type 1 diabetes or the type 2 db/db model of diabetes [19].
Positive_regulation (upregulated) of OPN associated with diabetes mellitus and renal disease
9) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.62 Pain Relevance 0.03
In the present study, we found that plasma OPN level, but not N-half OPN parallels with the severity of nephropathy and CAD in diabetes, suggesting that an increased plasma OPN level may be used as an indicator for screening diabetic vasculopathy.
Positive_regulation (increased) of OPN in plasma associated with coronary artery disease, diabetes mellitus and renal disease
10) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.71 Pain Relevance 0
Conversely, the presence of renal insufficiency could lead to elevated plasma OPN concentrations, forming a vicious cycle that exaggerates diabetic nephropathy and atherosclerosis.
Positive_regulation (elevated) of OPN in plasma associated with atherosclerosis, renal disease and renal insufficiency
11) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.73 Pain Relevance 0.15
At 24 h after infection plasma OPN concentrations were significantly elevated compared to baseline (P<0.01) and were further increased at 72 h after infection (P<0.01, figure 2A).
Positive_regulation (elevated) of OPN in plasma associated with infection
12) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.64 Pain Relevance 0
In experimental melioidosis in mice plasma and pulmonary OPN levels were also increased.
Positive_regulation (increased) of OPN in plasma associated with melioidosis
13) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2930856 Disease Relevance 1.59 Pain Relevance 0.11
Enhanced OPN production is not likely to be restricted to bacterial infections: elevated circulating OPN levels have previously been reported in patients with mycobacterial and fungal infections [35]–[38].
Positive_regulation (elevated) of OPN associated with fungal infection and bacterial infection
14) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.90 Pain Relevance 0
Other studies have reported that Opn expression is modulated by osteoblast stimulation in vivo, resulting in dramatically increased Opn [17,29].
Positive_regulation (increased) of Opn in osteoblast associated with osteoporosis
15) Confidence 0.57 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0
We have shown that osteopontin (OPN), a secreted inflammatory glycophosphoprotein, plays a pivotal role in cardiac fibrosis (11) and is often increased in the tissues of diabetic mouse models (11–13).
Positive_regulation (increased) of osteopontin associated with fibrosis, inflammation, diabetes mellitus and cardiovascular disorder under development
16) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.79 Pain Relevance 0.30
, IGFBP3, SPP1/OPN and TIMP1 were increased in PN and tumours relative to AN, with higher levels seen in tumours.
Positive_regulation (increased) of OPN associated with cancer
17) Confidence 0.49 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.06 Pain Relevance 0.14
Osteopontin levels are increased during murine melioidosis
Positive_regulation (increased) of Osteopontin associated with melioidosis
18) Confidence 0.46 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.65 Pain Relevance 0
Elevated plasma osteopontin levels in patients with culture proven melioidosis
Positive_regulation (Elevated) of osteopontin in plasma associated with melioidosis
19) Confidence 0.46 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.47 Pain Relevance 0.13
Activation of Opn, CatK, Sca-1 and Gapdh Genes
Positive_regulation (Activation) of Opn
20) Confidence 0.44 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.15 Pain Relevance 0

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