INT122902

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 56.30
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
plasma 12
aorta 6
macrophage 4
osteoblast 4
heart 4
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 8 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
Inflammation 506 98.92 Very High Very High Very High
fibrosis 299 98.04 Very High Very High Very High
Neuritis 20 97.96 Very High Very High Very High
cytokine 339 96.60 Very High Very High Very High
Inflammatory mediators 1 94.24 High High
chemokine 97 90.92 High High
depression 4 90.52 High High
metalloproteinase 15 89.84 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 768 100.00 Very High Very High Very High
Coronary Artery Disease 396 100.00 Very High Very High Very High
Multiple Sclerosis 19 100.00 Very High Very High Very High
Hyperoxia 245 99.98 Very High Very High Very High
Pneumonia 88 99.98 Very High Very High Very High
Renal Disease 298 99.96 Very High Very High Very High
Immunization 7 99.96 Very High Very High Very High
Renal Insufficiency 145 99.88 Very High Very High Very High
Stomach Cancer 116 99.84 Very High Very High Very High
Cancer 1641 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In turn, with the overexpression of the OPN protein in the Db-S cells (3.5-fold higher than the control Db cells and 6.5-fold higher than the Met-As cells), there was a significant increase in the migratory potential of these cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of OPN protein
1) Confidence 0.70 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.48 Pain Relevance 0
We therefore postulated that this level of OPN overexpression would have further consequences in the in vivo experiments.
Positive_regulation (overexpression) of Gene_expression (overexpression) of OPN
2) Confidence 0.70 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.52 Pain Relevance 0
SPP1/OPN has also been reported to be overexpressed in gastric cancers and increasing levels have been detected with progression of disease [41].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of OPN associated with disease and stomach cancer
3) Confidence 0.67 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.15 Pain Relevance 0.11
The overexpression of OPN correlates with an increased migration potential of cells, and the inhibition of OPN correlates with a decrease in migration.


Positive_regulation (overexpression) of Gene_expression (overexpression) of OPN
4) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.29 Pain Relevance 0
In contrast, the studies in the Db cells demonstrate that overexpression of OPN alone is not sufficient to effect a metastatic phenotype, as evidenced by the lack of correlation between increased OPN levels and the metastasis rate in the Db-S cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of OPN associated with metastasis
5) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.46 Pain Relevance 0
We confirmed this in subsequent experiments using Affymetrix U74Av2 GeneChip arrays, where OPN is seen to be overexpressed in the Met tumor compared with in the Db tumors (data not shown).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of OPN associated with cancer
6) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.93 Pain Relevance 0
Urquidi and colleagues [42] have demonstrated overexpression of OPN in sublines of the MDA-MB-435 breast tumor cell line that were selected for a high metastatic potential as compared with the non-metastatic sublines.
Positive_regulation (overexpression) of Gene_expression (overexpression) of OPN associated with breast cancer
7) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.09 Pain Relevance 0
In nonhuman studies, Oates and colleagues [44] have shown that increasing the expression of OPN is sufficient to produce a metastatic phenotype in a previously benign cell line (rat mammary tumor line).
Positive_regulation (increasing) of Gene_expression (expression) of OPN associated with cancer
8) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.07 Pain Relevance 0
Conversely, OPN expression was successfully elevated in Db-S.
Positive_regulation (elevated) of Gene_expression (expression) of OPN
9) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0 Pain Relevance 0
Our studies suggest that, in the PyV-mT model, an active PI3-K pathway is associated with or induces OPN expression.
Positive_regulation (induces) of Gene_expression (expression) of OPN
10) Confidence 0.61 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.42 Pain Relevance 0
Furthermore, OPN expression has been shown to be upregulated in the vascular wall of diabetic patients and diabetic animal models, which might be induced by high glucose and advanced glycation endproduct [9,13-15].
Positive_regulation (upregulated) of Gene_expression (expression) of OPN associated with diabetes mellitus
11) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.57 Pain Relevance 0.07
In rat models of streptozotocin- or high-fat diet-induced diabetic nephropathy, OPN expression is significantly upregulated in the renal cortex and aorta [31,32], and increased OPN expression is strongly correlated with severe diabetic albuminuria and glomerulosclerosis [19,20].
Positive_regulation (upregulated) of Gene_expression (expression) of OPN in aorta associated with diabetes mellitus, renal disease and albuminuria
12) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.68 Pain Relevance 0
In rat models of streptozotocin- or high-fat diet-induced diabetic nephropathy, OPN expression is significantly upregulated in the renal cortex and aorta [31,32], and increased OPN expression is strongly correlated with severe diabetic albuminuria and glomerulosclerosis [19,20].
Positive_regulation (increased) of Gene_expression (expression) of OPN in aorta associated with diabetes mellitus, renal disease and albuminuria
13) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.68 Pain Relevance 0
Here, we show that the production of OPN is enhanced during clinical and experimental melioidosis.
Positive_regulation (enhanced) of Gene_expression (production) of OPN associated with melioidosis
14) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.29 Pain Relevance 0.04
Enhanced OPN production is not likely to be restricted to bacterial infections: elevated circulating OPN levels have previously been reported in patients with mycobacterial and fungal infections [35]–[38].
Positive_regulation (Enhanced) of Gene_expression (production) of OPN associated with fungal infection and bacterial infection
15) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.86 Pain Relevance 0
To determine whether OPN production is enhanced during melioidosis in mice, we intranasally infected WT mice with B. pseudomallei and measured OPN levels in plasma and whole lung homogenates (figure 2A–B).
Spec (whether) Positive_regulation (enhanced) of Spec (whether) Gene_expression (production) of OPN in plasma associated with melioidosis
16) Confidence 0.60 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 0.65 Pain Relevance 0
The results suggest that OPN expression in Schwann cells is easily induced by immunostimulation, and further enhanced by the inflammatory reaction in EAN.
Positive_regulation (induced) of Gene_expression (expression) of OPN in Schwann cells associated with inflammation, immunization and neuritis
17) Confidence 0.50 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531104 Disease Relevance 1.07 Pain Relevance 0.67
Even after recovery from hindlimb paralysis, at 24 days post-immunization, OPN expression remained elevated in the Schwann cells.
Positive_regulation (elevated) of Gene_expression (expression) of OPN in Schwann cells associated with immunization and paralysis
18) Confidence 0.50 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15531104 Disease Relevance 0.98 Pain Relevance 0.66
Therefore, in our Met model, due to the activation of PI3-K, OPN gene expression may be directly activated via PI3-K, or it may be activated further downstream or via cross-talk through the MAPK pathway.
Positive_regulation (activated) of Gene_expression (expression) of OPN gene
19) Confidence 0.47 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.46 Pain Relevance 0
There were also protoxicant genes, such as osteopontin (OPN), with elevated mRNA expression levels in the B6 mice as compared to the SJL mice and with intermediate levels in the F1 mice, suggesting that they may play a role in exacerbating liver injury after APAP treatment.
Positive_regulation (elevated) of Gene_expression (expression) of osteopontin in liver associated with injury
20) Confidence 0.46 Published 2006 Journal Chem. Res. Toxicol. Section Abstract Doc Link 16485898 Disease Relevance 1.33 Pain Relevance 0.07

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