INT122920

Context Info Confidence 0.65 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.19 Pain Relevance 0.99

nucleolus (MSN) plasma membrane (MSN) cytoskeleton (MSN) nucleus (MSN) cytoplasm (MSN)

Anatomy Link Frequency urine 1 MSN (Homo sapiens)

Pain Link Frequency Relevance Heat Oxycodone 10 100.00 Pain 1 96.20 Analgesic 1 92.60 Hippocampus 22 61.92 cerebral cortex 12 5.00 Thalamus 10 5.00 cytokine 4 5.00 midbrain 2 5.00 Peripheral nervous system 2 5.00 Neuritis 2 5.00

Disease Link Frequency Relevance Heat Pain 1 96.20 Cancer 3 95.68 Adhesions 32 50.00 Fasciculation 26 5.00 Neuritis 2 5.00 Anuria 2 5.00 Hypothermia 2 5.00 Increased Venous Pressure Under Development 2 5.00 Stroke 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

5000), Ezrin/Radixin/Moesin (1?

Gene_expression (/) of Moesin

1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0.03

5000), Ezrin/Radixin/Moesin (1?

Gene_expression (/) of Moesin

2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0.03

Using an aqueous pH 9 ammonium acetate buffer and CE-MSn (n < or = 5), OCOD and its phase I metabolites produced by O-demethylation, N-demethylation, 6-ketoreduction and N-oxidation (such as oxymorphone, noroxycodone, noroxymorphone, 6-oxycodol, nor-6-oxycodol, oxycodone-N-oxide and 6-oxycodol-N-oxide) and phase II conjugates with glucuronic acid of several of these compounds could be detected in alkaline solid-phase extracts of a patient urine that was collected during a pharmacotherapy episode with daily ingestion of 240-320 mg of OCOD chloride.

Gene_expression (produced) of CE-MSn in urine associated with oxycodone

3) Confidence 0.40 Published 2004 Journal J Chromatogr A Section Abstract Doc Link 15532584 Disease Relevance 0.19 Pain Relevance 0.93

General Comments

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